MLN
Promotilin
Also known as: MOTI_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P12872
- Gene
- MLN
- Ensembl
- ENSG00000096395
- Chromosome
- 6
- Canonical length
- 115 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>P12872|MLN
1 MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS LSVWQRSGEE
61 GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT LEGLLSEMLP QHAAKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 239 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 239 nTPM
- small intestine: 41 nTPM
- appendix: 0.5 nTPM
- colon: 0.4 nTPM
- lymph node: 0.3 nTPM
- skin: 0.3 nTPM
Single-cell type
- neuroendocrine cells: 1,623 nCPM
- epicardial cells: 2.3 nCPM
- foveolar cells: 1.5 nCPM
- gastric progenitor cells: 1.3 nCPM
- cdc: 0.5 nCPM
- fibro-adipogenic progenitors: 0.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 2.8 nTPM
- pons: 2.7 nTPM
- white matter: 2.6 nTPM
- hypothalamus: 2.4 nTPM
- midbrain: 2.1 nTPM
- thalamus: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.51
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
- hormone activity
- motilin receptor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MLN as an antibody target. Whether an autoantibody or antibody against MLN could matter depends on whether native MLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MLN is annotated as secreted, so native MLN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label MLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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