Seroatlas · Human Serome Atlas

MKX

Homeobox protein Mohawk

Also known as: C10orf48, IRXL1, MGC39616, MKX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYA7
Gene: MKX
Ensembl: ENSG00000150051
Chromosome: 10
Canonical length: 352 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q8IYA7|MKX
     1  MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIPDGPP LKDNLGLRHR
    61  RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGS QMTLVQVSNW
   121  FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDDSCSEDGE NPPRTHMNEG
   181  GYNTPVHHPV IKSENSVIKA GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT
   241  MMGKTRQRNH SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGSNKGE SAANRKGPSK
   301  DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ QF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MKX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

prostate: 15 nTPM
ovary: 11 nTPM
blood vessel: 6 nTPM
seminal vesicle: 5 nTPM
fallopian tube: 4.9 nTPM
pituitary gland: 4.5 nTPM

Single-cell type

gonadotrophs: 558 nCPM
pituicytes/fscs: 133 nCPM
ependymal cells: 90 nCPM
thyrotrophs: 77 nCPM
adipocytes: 50 nCPM
respiratory ciliated cells: 46 nCPM

Immune cell

myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 21 nTPM
cerebellum: 14 nTPM
pons: 14 nTPM
medulla oblongata: 13 nTPM
spinal cord: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.88
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MKX as an antibody target. Whether an autoantibody or antibody against MKX could matter depends on whether native MKX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MKX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MKX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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