Seroatlas · Human Serome Atlas

MKRN2OS

MKRN2 opposite strand protein

Also known as: C3orf83, MKRN2-AS1, MKROS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BPM6
Gene
MKRN2OS
Ensembl
ENSG00000225526
Chromosome
3
Canonical length
223 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for MKRN2OS in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>H3BPM6|MKRN2OS
     1  MHCAEAGKAL IKFNHCEKYI YSFSVPQCCP LCQQDLGSRK LEDAPVSIAN PFTNGHQEKC
    61  SFLLRPTQGT FLREYDGRSD LHVGITNTNG VVYNYSAHGV QRDGEGWEES ISIPLLQPNM
   121  YGMMEQWDKY LEDFSTSGAW LPHRYEDNHH NCYSYALTFI NCVLMAEGRQ QLDKGEFTEK
   181  YVVPRTRLAS KFITLYRAIR EHGFYVTDCP QQQAQPPEGG GLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MKRN2OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
9.4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 9.4 nTPM
  • duodenum: 6.7 nTPM
  • epididymis: 6.7 nTPM
  • small intestine: 6.3 nTPM
  • salivary gland: 5.7 nTPM
  • esophagus: 4.7 nTPM

Single-cell type

  • cardiomyocytes: 267 nCPM
  • adipocytes: 156 nCPM
  • epicardial cells: 89 nCPM
  • esophageal apical cells: 61 nCPM
  • myonuclei: 61 nCPM
  • retinal ganglion cells: 54 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 9 nTPM
  • cerebral cortex: 4.1 nTPM
  • pons: 3.6 nTPM
  • basal ganglia: 3.5 nTPM
  • hypothalamus: 3.4 nTPM
  • white matter: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
DepMap mean gene effect
0.04
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

  • MKRN2 opposite strand protein-like
  • MKRN2 opposite strand protein-like, C-terminal
  • MKRN2 opposite strand protein-like, N-terminal
  • DUF4796 C-terminal
  • DUF4796 N-terminal

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MKRN2OS as an antibody target. Whether an autoantibody or antibody against MKRN2OS could matter depends on whether native MKRN2OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MKRN2OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MKRN2OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MKRN2OS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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