Seroatlas · Human Serome Atlas

MIX23

Protein MIX23

Also known as: CCDC58, FLJ33273, MIX23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4VC31
Gene
MIX23
Ensembl
ENSG00000160124
Chromosome
3
Canonical length
144 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>Q4VC31|MIX23
     1  MAAPSGGVNC EEFAEFQELL KVMRTIDDRI VHELNTTVPT ASFAGKIDAS QTCKQLYESL
    61  MAAHASRDRV IKNCIAQTSA VVKNLREERE KNLDDLTLLK QLRKEQTKLK WMQSELNVEE
   121  VVNDRSWKVF NERCRIHFKP PKNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIX23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • liver: 46 nTPM
  • tongue: 44 nTPM
  • kidney: 43 nTPM
  • rectum: 27 nTPM
  • colon: 27 nTPM

Single-cell type

  • esophageal suprabasal cells: 72 nCPM
  • esophageal basal cells: 68 nCPM
  • parietal cells: 62 nCPM
  • hepatocytes: 56 nCPM
  • myonuclei: 54 nCPM
  • extravillous trophoblasts: 52 nCPM

Immune cell

  • plasmacytoid DC: 29 nTPM
  • naive CD4 T-cell: 23 nTPM
  • naive CD8 T-cell: 22 nTPM
  • memory B-cell: 21 nTPM
  • memory CD8 T-cell: 20 nTPM
  • memory CD4 T-cell: 20 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • midbrain: 11 nTPM
  • pons: 11 nTPM
  • white matter: 11 nTPM
  • cerebellum: 11 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Intermembrane space protein MIX23
  • Intermembrane space protein MIX23

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIX23 as an antibody target. Whether an autoantibody or antibody against MIX23 could matter depends on whether native MIX23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIX23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIX23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIX23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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