Seroatlas · Human Serome Atlas

MISP3

Uncharacterized protein MISP3

Also known as: MISP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FF7
Gene
MISP3
Ensembl
ENSG00000141854
Chromosome
19
Canonical length
219 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MISP3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q96FF7|MISP3
     1  METPIEREIR RSCEREESLR RSRGLSPGRA GRELVELRVR PVLNLPGPGP ALPRALERAR
    61  AGAQMQRDIE REAHRQAALA RPAVPEPRAR SPPQPLGELK RFFEAAAGSG SSAGAGDGAG
   121  PQRLPEPGGR PRSAVQGGCR VLGSAPPPFT PSLLEQEVRA VREREQELQR QRRSVYGTAE
   181  FKEPTPSLTA SRGDGKLVVI WPPRRKVSEN GLEQEERKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MISP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 18 nTPM
  • cerebellum: 18 nTPM
  • amygdala: 16 nTPM
  • hippocampal formation: 16 nTPM
  • kidney: 15 nTPM
  • hypothalamus: 14 nTPM

Single-cell type

  • platelets: 52 nCPM
  • gastric chief cells: 24 nCPM
  • ependymal cells: 18 nCPM
  • other brain neurons: 18 nCPM
  • brain excitatory neurons: 14 nCPM
  • oligodendrocytes: 12 nCPM

Immune cell

  • neutrophil: 1 nTPM
  • total PBMC: 0.8 nTPM
  • eosinophil: 0.3 nTPM
  • gdT-cell: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • white matter: 6.1 nTPM
  • cerebral cortex: 4.7 nTPM
  • hypothalamus: 3.9 nTPM
  • pons: 3.3 nTPM
  • spinal cord: 3.1 nTPM
  • medulla oblongata: 2.9 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MISP3 as an antibody target. Whether an autoantibody or antibody against MISP3 could matter depends on whether native MISP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MISP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MISP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MISP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...