MIOX
Inositol oxygenase
Also known as: ALDRL6, MIOX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UGB7
- Gene
- MIOX
- Ensembl
- ENSG00000100253
- Chromosome
- 22
- Canonical length
- 285 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
285 residues, UniProt reviewed canonical sequence.
>Q9UGB7|MIOX
1 MKVTVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH
61 AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG
121 LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ
181 PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL
241 AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MIOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.23
- Highest tissue expression
- 654 nTPM
Expression across tissuesHPA
Tissue
- kidney: 654 nTPM
- thyroid gland: 14 nTPM
- gallbladder: 5 nTPM
- cerebral cortex: 1.3 nTPM
- pancreas: 1 nTPM
- stomach: 1 nTPM
Single-cell type
- proximal tubule cells: 498 nCPM
- renal connecting tubule cells: 35 nCPM
- podocytes: 33 nCPM
- distal convoluted tubule cells: 33 nCPM
- renal collecting duct intercalated cells: 28 nCPM
- loop of henle epithelial cells: 20 nCPM
Immune cell
- basophil: 0.8 nTPM
- memory B-cell: 0.2 nTPM
- memory CD8 T-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
- naive B-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
Brain region
- cerebellum: 2.5 nTPM
- cerebral cortex: 2.2 nTPM
- pons: 1.7 nTPM
- choroid plexus: 1.6 nTPM
- white matter: 1.6 nTPM
- hypothalamus: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.49
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- inositol catabolic process
Molecular functions
- alcohol dehydrogenase (NADP+) activity
- ferric iron binding
- oxidoreductase activity, acting on NAD(P)H
- inositol oxygenase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Inositol oxygenase
- Myo-inositol oxygenase
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MIOX as an antibody target. Whether an autoantibody or antibody against MIOX could matter depends on whether native MIOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MIOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MIOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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