Seroatlas · Human Serome Atlas

MINPP1

Multiple inositol polyphosphate phosphatase 1

Also known as: MINP1_HUMAN, MIPP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNW1
Gene
MINPP1
Ensembl
ENSG00000107789
Chromosome
10
Canonical length
487 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q9UNW1|MINPP1
     1  MLRAPGCLLR TSVAPAAALA AALLSSLARC SLLEPRDPVA SSLSPYFGTK TRYEDVNPVL
    61  LSGPEAPWRD PELLEGTCTP VQLVALIRHG TRYPTVKQIR KLRQLHGLLQ ARGSRDGGAS
   121  STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI
   181  TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE
   241  KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL IQVAFFTCSF DLAIKGVKSP
   301  WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFQHLDKA VEQKQRSQPI
   361  SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKKQMH RKFRSGLIVP YASNLIFVLY
   421  HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLKN HYKDILQSCQ TSEECELARA
   481  NSTSDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • liver: 27 nTPM
  • adrenal gland: 20 nTPM
  • placenta: 18 nTPM
  • duodenum: 17 nTPM
  • kidney: 16 nTPM

Single-cell type

  • erythrocyte progenitors: 225 nCPM
  • megakaryocyte-erythroid progenitors: 121 nCPM
  • megakaryocyte progenitors: 80 nCPM
  • hepatocytes: 69 nCPM
  • goblet cells: 34 nCPM
  • prostatic glandular cells: 33 nCPM

Immune cell

  • T-reg: 17 nTPM
  • myeloid DC: 14 nTPM
  • intermediate monocyte: 14 nTPM
  • memory CD8 T-cell: 13 nTPM
  • non-classical monocyte: 13 nTPM
  • NK-cell: 12 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • hypothalamus: 12 nTPM
  • white matter: 10 nTPM
  • spinal cord: 9.4 nTPM
  • cerebellum: 9.3 nTPM
  • midbrain: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MINPP1.

Disease | AllUniProt

Conditions MINPP1 is implicated in, by any mechanism.

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 110 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINPP1 as an antibody target. Whether an autoantibody or antibody against MINPP1 could matter depends on whether native MINPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINPP1 is annotated at the cell surface, where native MINPP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MINPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MINPP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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