Seroatlas · Human Serome Atlas

MINDY4B

Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B

Also known as: C3orf76, FAM188B2, MIY4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MYZ0
Gene: MINDY4B
Ensembl: ENSG00000214237
Chromosome: 3
Canonical length: 460 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>A8MYZ0|MINDY4B
     1  MDMEVLGQEQ SSEQLDLEEI SRKISFLDKW REIFSYHRLG TNNSTPQNHE GNHTSADENE
    61  DGTGLSQPKG QGHLPSSGLC SIPNPSIISS KLGGFPISLA MATKLRQILF GNTVHVFSYN
   121  WKKAYFRFHD PSSELAFTLE VGKGGARSIQ MAVQGSIIKY LLFTRKGKDC NLGNLCEISK
   181  KEQEQALAAA LAGILWAAGA AQKATICLVT EDIYVASTPD YSVDNFTERL QLFEFLEKEA
   241  AEKFIYDHLL CFRGEGSHGV ILFLYSLIFS RTFERLQMDL DVTTTQLLQP NAGGFLCRQA
   301  VLNMILTGRA SPNVFNGCEE GKSQETLHGV LTRSDVGYLQ WGKDASEDDR LSQVGSMLKT
   361  PKLPIWLCNI NGNYSILFCT NRQLLSDWKM ERLFDLYFYS GQPSQKKLVR LTIDTHSHHW
   421  ERDQQEEKHG PRRRFSPVEM AIRTKWSEAT INWNGTVPFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINDY4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 3.6 nTPM
retina: 0.8 nTPM
cerebral cortex: 0.3 nTPM
endometrium: 0.3 nTPM
adrenal gland: 0.2 nTPM
fallopian tube: 0.1 nTPM

Single-cell type

epicardial cells: 6.8 nCPM
neutrophils: 3.8 nCPM
peritubular myoid cells: 2.6 nCPM
respiratory ionocytes: 2.5 nCPM
mucous neck cells: 2 nCPM
retinal horizontal cells: 2 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 3.3 nTPM
cerebral cortex: 0.7 nTPM
thalamus: 0.4 nTPM
white matter: 0.4 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0

OntologyGO

Biological processes

protein K48-linked deubiquitination

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINDY4B as an antibody target. Whether an autoantibody or antibody against MINDY4B could matter depends on whether native MINDY4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINDY4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MINDY4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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