Seroatlas · Human Serome Atlas

MINDY4

Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

Also known as: C7orf67, FAM188B, FLJ22374, MINY4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4G0A6
Gene
MINDY4
Ensembl
ENSG00000106125
Chromosome
7
Canonical length
757 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination and proteolysis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q4G0A6|MINDY4
     1  MDSLFVEEVA ASLVREFLSR KGLKKTCVTM DQERPRSDLS INNRNDLRKV LHLEFLYKEN
    61  KAKENPLKTS LELITRYFLD HFGNTANNFT QDTPIPALSV PKKNNKVPSR CSETTLVNIY
   121  DLSDEDAGWR TSLSETSKAR HDNLDGDVLG NFVSSKRPPH KSKPMQTVPG ETPVLTSAWE
   181  KIDKLHSEPS LDVKRMGENS RPKSGLIVRG MMSGPIASSP QDSFHRHYLR RSSPSSSSTQ
   241  PQEESRKVPE LFVCTQQDIL ASSNSSPSRT SLGQLSELTV ERQKTTASSP PHLPSKRLPP
   301  WDRARPRDPS EDTPAVDGST DTDRMPLKLY LPGGNSRMTQ ERLERAFKRQ GSQPAPVRKN
   361  QLLPSDKVDG ELGALRLEDV EDELIREEVI LSPVPSVLKL QTASKPIDLS VAKEIKTLLF
   421  GSSFCCFNEE WKLQSFSFSN TASLKYGIVQ NKGGPCGVLA AVQGCVLQKL LFEGDSKADC
   481  AQGLQPSDAH RTRCLVLALA DIVWRAGGRE RAVVALASRT QQFSPTGKYK ADGVLETLTL
   541  HSLTCYEDLV TFLQQSIHQF EVGPYGCILL TLSAILSRST ELIRQDFDVP TSHLIGAHGY
   601  CTQELVNLLL TGKAVSNVFN DVVELDSGDG NITLLRGIAA RSDIGFLSLF EHYNMCQVGC
   661  FLKTPRFPIW VVCSESHFSI LFSLQPGLLR DWRTERLFDL YYYDGLANQQ EQIRLTIDTT
   721  QTISEDTDND LVPPLELCIR TKWKGASVNW NGSDPIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINDY4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 12 nTPM
  • fallopian tube: 11 nTPM
  • blood vessel: 10 nTPM
  • lung: 9 nTPM
  • testis: 8.6 nTPM
  • ovary: 8.5 nTPM

Single-cell type

  • ependymal cells: 19 nCPM
  • endometrial ciliated cells: 7.8 nCPM
  • gonadotrophs: 6.8 nCPM
  • fallopian tube ciliated cells: 6.4 nCPM
  • mesothelial cells: 4.5 nCPM
  • thyrotrophs: 4.2 nCPM

Immune cell

  • MAIT T-cell: 0.5 nTPM
  • myeloid DC: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • midbrain: 15 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 12 nTPM
  • medulla oblongata: 11 nTPM
  • hypothalamus: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINDY4 as an antibody target. Whether an autoantibody or antibody against MINDY4 could matter depends on whether native MINDY4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINDY4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MINDY4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MINDY4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...