Seroatlas · Human Serome Atlas

MINDY2

Ubiquitin carboxyl-terminal hydrolase MINDY-2

Also known as: FAM63B, KIAA1164, MINY2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBR6
Gene
MINDY2
Ensembl
ENSG00000128923
Chromosome
15
Canonical length
621 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in chromatin remodeling and proteolysis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>Q8NBR6|MINDY2
     1  MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG GNGLGAAAAR
    61  RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA PLRGQYKVTA SPETAVAGVG
   121  HELGTAGDAG ARPDLAGTCQ AELTAAGSEE PSSAGGLSSS CSDPSPPGES PSLDSLESFS
   181  NLHSFPSSCE FNSEEGAENR VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ
   241  SVYHIKWIQW KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG
   301  DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE YTPECIVFDL
   361  LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS DNSELVSEGF VAEQFLNNTA
   421  TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS TMTKYKGQLY LLVTDQGFLT EEKVVWESLH
   481  NVDGDGNFCD SEFHLRPPSD PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI
   541  SDLELAKKLQ EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK
   601  RKEPREKDKE KEKEKNSCVI L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINDY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 17 nTPM
  • retina: 15 nTPM
  • heart muscle: 10 nTPM
  • kidney: 9.5 nTPM
  • spinal cord: 9 nTPM
  • thyroid gland: 9 nTPM

Single-cell type

  • early spermatids: 285 nCPM
  • papillary tip epithelial cells: 210 nCPM
  • extravillous trophoblasts: 204 nCPM
  • respiratory basal cells: 192 nCPM
  • prostatic club cells: 186 nCPM
  • late spermatids: 184 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • MAIT T-cell: 2 nTPM
  • naive B-cell: 1.5 nTPM
  • neutrophil: 1.3 nTPM
  • non-classical monocyte: 1.3 nTPM
  • eosinophil: 1.2 nTPM

Brain region

  • cerebellum: 33 nTPM
  • hypothalamus: 27 nTPM
  • midbrain: 26 nTPM
  • thalamus: 26 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINDY2 as an antibody target. Whether an autoantibody or antibody against MINDY2 could matter depends on whether native MINDY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINDY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MINDY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MINDY2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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