Seroatlas · Human Serome Atlas

MINDY1

Ubiquitin carboxyl-terminal hydrolase MINDY-1

Also known as: FAM63A, FLJ11280, MINDY-1, MINY1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5J2
Gene: MINDY1
Ensembl: ENSG00000143409
Chromosome: 1
Canonical length: 469 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables K48-linked deubiquitinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and cysteine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q8N5J2|MINDY1
     1  MEYHQPEDPA PGKAGTAEAV IPENHEVLAG PDEHPQDTDA RDADGEARER EPADQALLPS
    61  QCGDNLESPL PEASSAPPGP TLGTLPEVET IRACSMPQEL PQSPRTRQPE PDFYCVKWIP
   121  WKGEQTPIIT QSTNGPCPLL AIMNILFLQW KVKLPPQKEV ITSDELMAHL GNCLLSIKPQ
   181  EKSEGLQLNF QQNVDDAMTV LPKLATGLDV NVRFTGVSDF EYTPECSVFD LLGIPLYHGW
   241  LVDPQSPEAV RAVGKLSYNQ LVERIITCKH SSDTNLVTEG LIAEQFLETT AAQLTYHGLC
   301  ELTAAAKEGE LSVFFRNNHF STMTKHKSHL YLLVTDQGFL QEEQVVWESL HNVDGDSCFC
   361  DSDFHLSHSL GKGPGAEGGS GSPETQLQVD QDYLIALSLQ QQQPRGPLGL TDLELAQQLQ
   421  QEEYQQQQAA QPVRMRTRVL SLQGRGATSG RPAGERRQRP KHESDCILL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINDY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 44 nTPM
pancreas: 42 nTPM
spinal cord: 42 nTPM
heart muscle: 29 nTPM
parathyroid gland: 29 nTPM
salivary gland: 28 nTPM

Single-cell type

platelets: 476 nCPM
esophageal apical cells: 150 nCPM
neutrophils: 92 nCPM
late spermatids: 67 nCPM
megakaryocytes: 56 nCPM
renal collecting duct intercalated cells: 52 nCPM

Immune cell

basophil: 100 nTPM
neutrophil: 94 nTPM
eosinophil: 57 nTPM
myeloid DC: 12 nTPM
total PBMC: 10 nTPM
classical monocyte: 10 nTPM

Brain region

white matter: 153 nTPM
medulla oblongata: 126 nTPM
basal ganglia: 105 nTPM
pons: 100 nTPM
midbrain: 94 nTPM
cerebellum: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MINDY1 as an antibody target. Whether an autoantibody or antibody against MINDY1 could matter depends on whether native MINDY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MINDY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MINDY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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