MINAR2

Protein identityUniProt · HPA

UniProt accession

P59773

Gene

MINAR2

Ensembl

ENSG00000186367

Chromosome

5

Canonical length

190 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

Enables cholesterol binding activity. Involved in angiogenesis. Located in endoplasmic reticulum. Implicated in autosomal recessive nonsyndromic deafness. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>P59773|MINAR2
     1  MDLSVLPNNN HPDKFLQLDV KSLTRSSALL QASLVRFPGG NYPAAQHWQN LVYSQREKKN
    61  IAAQRIRGSS ADSLVTADSP PPSMSSVMKN NPLYGDLSLE EAMEERKKNP SWTIEEYDKH
   121  SLHTNLSGHL KENPNDLRFW LGDMYTPGFD TLLKKEEKQE KHSKFCRMGL ILLVVISILV
   181  TIVTIITFFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

33 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MINAR2.

Disease | AllUniProt

Conditions MINAR2 is implicated in, by any mechanism.

• Deafness, autosomal recessive, 120 (DFNB120) MIM:620238

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 9 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hearing loss, autosomal recessive 120

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

DepMap mean gene effect

0.03

DepMap dependency class

none

OntologyGO

Biological processes

• angiogenesis
• cholesterol homeostasis
• exploration behavior
• gene expression
• homeostasis of number of cells within a tissue
• inner ear auditory receptor cell differentiation
• inner ear receptor cell stereocilium organization
• neuron apoptotic process
• sensory perception of sound
• walking behavior

Molecular functions

• cholesterol binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• lysosomal membrane
• stereocilium

Protein domainsUniProt · Pfam · InterPro

• Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal
• Major intrinsically disordered Notch2-binding receptor 1-like
• MINAR1 C-terminal domain

KeywordsUniProt

• Deafness
• Endoplasmic reticulum
• Glycoprotein
• Lysosome
• Membrane
• Non-syndromic deafness
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MINAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOTCH2