MINAR1

Protein identityUniProt · HPA

UniProt accession

Q9UPX6

Gene

MINAR1

Ensembl

ENSG00000169330

Chromosome

15

Canonical length

916 aa

Protein class

Predicted membrane proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

Involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

916 residues, UniProt reviewed canonical sequence.

>Q9UPX6|MINAR1
     1  METSQETSLF LVKILEELDS KQNTVSYQDL CKSLCARFDL SQLAKLRSVL FYTACLDPNF
    61  PATLFKDKMK CTVNNQQSKK IMVAADIVTI FNLIQMNGGA AKEKLPTGRQ KVRKKEASFE
   121  SCRSDTEICN AAECEPLNCE LSERSFSRGY PIRQSSKCRK MDCKDCPQFV PASEPNFLLG
   181  VSKEVKNRAA SLDRLQALAP YSVTSPQPCE MQRTYFPMNI ENESISDQDS LPINQSIKET
   241  FISNEEPFVV QSCVQKRNIF KEDFHNLMAV SPSLVGPISK AENEHREPQS RKEPHKPPFF
   301  NHSFEMPYNS QYLNPVYSPV PDKRRAKHES LDDLQASTYF GPTPVMGTQE ARRCLGKPNK
   361  QTPWPAKSWS LNTEEVPDFE RSFFNRNPSE EKLHYPNASS QTPNFPAPER RPTYLVPKDQ
   421  QPILPIAYAA KQNGLKSKEI SSPVDLEKHE PVKKFKDKSI NCTSGQLSSD TSSVGTQTEH
   481  VLEPKKCRDL CTSGQGKYSD RHTMKHSDDD SEIVSDDISD IFRFLDDMSI SGSTGVIQSS
   541  CYNSTGSLSQ LHKSDCDSSP EHNLTKIANG VPNSKGDKGN RPENTHHSEE ELKTSVCKLV
   601  LRIGEIERKL ESLSGVRDEI SQVLGKLNKL DQKMQQPEKV SVQIDLNSLT SEGPSDDSAS
   661  PRMFHAHSGS HGPKLENNPD WCCSDASGSN SESLRVKALK KSLFTRPSSR SLTEENSATE
   721  SKIASISNSP RDWRTITYTN RVGLNEEEIK DTGPGDNKDW HRKSKEADRQ YDIPPQHRLP
   781  KQPKDGFLVE QVFSPHPYPA SLKAHMKSNP LYTDMRLTEL AEVKRGQPSW TIEEYARNAG
   841  DKGKLTALDL QTQESLNPNN LEYWMEDIYT PGYDSLLKRK EAEFRRAKVC KIAALIAAAA
   901  CTVILVIVVP ICTMKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MINAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

9.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• negative regulation of angiogenesis
• negative regulation of cell growth
• negative regulation of cell population proliferation
• negative regulation of neuron projection development
• negative regulation of protein ubiquitination
• negative regulation of TOR signaling

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal
• Major intrinsically disordered Notch2-binding receptor 1-like
• MINAR1 C-terminal domain
• MINAR1, N-terminal helical domain
• MINAR1, N-terminal helical domain

KeywordsUniProt

• Angiogenesis
• Cell membrane
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MINAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOTCH2