Seroatlas · Human Serome Atlas

MIGA1

Mitoguardin 1

Also known as: FAM73A, FLJ35093, MIGA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NAN2
Gene
MIGA1
Ensembl
ENSG00000180488
Chromosome
1
Canonical length
632 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Located in mitochondrion and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q8NAN2|MIGA1
     1  MSDCCSAPGI SWEAGVGRPA VPGLELQIRR GAMSEETVSE SQFSLKTAAL RVFDLPLTWY
    61  YSLSQIKFSP VAKKLFVVTA VSAISVIFLA HHFKRKRGKK KGKILPWEPE HLILEYTKRA
   121  ASDKGSSCSS SRQNLTLSLS STKDKGSQVC NYANGGLFSK YSGSAQSLAS VQSVNSCHSC
   181  ACGNSNSWDK ADEDDIKLVN IPVTTPENLY LMGMELFEEA LRRWEQALTF RNRQAEDEAC
   241  GSIKLGAGDA IAEENVDDII STEFIHKLEA LLQRAYRLQE EFEATLGASD PNSLADDIDK
   301  DTDITMKGNV EDFGLRDTLS IASTDSFASA AELAEHREVR HTYSLESLCH CPFYEEAMHL
   361  VEEGKIYSRV LRTEMLECLG DSDFLAKLHC IRQAFQVILS ESANRIFLAE SGRKILSALI
   421  VKARKNPKKF EDVFDEMIYF LEQTDHWGST EMELAARGVK NLNFYDVVLD FILMDSFEDL
   481  ENPPTSIQNV VNNRWLNSSF KETAVASSCW SVLKQKRQQM KIPDGFFAHF YAICEHISPV
   541  LAWGFLGPRN SLYDLCCFFK NQVLLFLKDI FDFEKVRYSS TETLAEDLMQ LLIRRTELLM
   601  AYLEADALRH TSSCLSSHGH VMSTGLLEAK VQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIGA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 17 nTPM
  • parathyroid gland: 17 nTPM
  • thyroid gland: 15 nTPM
  • kidney: 14 nTPM
  • spinal cord: 14 nTPM
  • breast: 13 nTPM

Single-cell type

  • oligodendrocytes: 161 nCPM
  • thyrotrophs: 134 nCPM
  • lactotrophs: 129 nCPM
  • corticotrophs: 126 nCPM
  • distal convoluted tubule cells: 112 nCPM
  • podocytes: 109 nCPM

Immune cell

  • basophil: 3.4 nTPM
  • intermediate monocyte: 2.7 nTPM
  • eosinophil: 2.5 nTPM
  • NK-cell: 2.4 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • classical monocyte: 2.1 nTPM

Brain region

  • white matter: 53 nTPM
  • pons: 40 nTPM
  • medulla oblongata: 39 nTPM
  • basal ganglia: 38 nTPM
  • hypothalamus: 38 nTPM
  • spinal cord: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIGA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIGA1 as an antibody target. Whether an autoantibody or antibody against MIGA1 could matter depends on whether native MIGA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIGA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIGA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIGA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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