Seroatlas · Human Serome Atlas

MID1IP1

Mid1-interacting protein 1

Also known as: FLJ10386, G12-like, M1IP1_HUMAN, MIG12, STRAIT11499, THRSPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPA3
Gene: MID1IP1
Ensembl: ENSG00000165175
Chromosome: X
Canonical length: 183 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable enzyme activator activity and ligase regulator activity. Predicted to be involved in several processes, including negative regulation of microtubule depolymerization; positive regulation of fatty acid biosynthetic process; and positive regulation of ligase activity. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9NPA3|MID1IP1
     1  MMQICDTYNQ KHSLFNAMNR FIGAVNNMDQ TVMVPSLLRD VPLADPGLDN DVGVEVGGSG
    61  GCLEERTPPV PDSGSANGSF FAPSRDMYSH YVLLKSIRND IEWGVLHQPP PPAGSEEGSA
   121  WKSKDILVDL GHLEGADAGE EDLEQQFHYH LRGLHTVLSK LTRKANILTN RYKQEIGFGN
   181  WGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MID1IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 155 nTPM

Expression across tissuesHPA

Tissue

midbrain: 155 nTPM
spinal cord: 147 nTPM
skeletal muscle: 141 nTPM
basal ganglia: 131 nTPM
hippocampal formation: 116 nTPM
amygdala: 109 nTPM

Single-cell type

alveolar cells type 2: 309 nCPM
neutrophils: 201 nCPM
transitional alveolar cells: 109 nCPM
esophageal apical cells: 107 nCPM
esophageal suprabasal cells: 106 nCPM
epididymal principal cells: 105 nCPM

Immune cell

eosinophil: 16 nTPM
neutrophil: 8.1 nTPM
basophil: 3.7 nTPM
non-classical monocyte: 2 nTPM
classical monocyte: 1.9 nTPM
memory CD4 T-cell: 1.4 nTPM

Brain region

basal ganglia: 231 nTPM
white matter: 223 nTPM
thalamus: 203 nTPM
midbrain: 193 nTPM
cerebral cortex: 181 nTPM
medulla oblongata: 179 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.58
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MID1IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MID1IP1 as an antibody target. Whether an autoantibody or antibody against MID1IP1 could matter depends on whether native MID1IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MID1IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MID1IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...