Seroatlas · Human Serome Atlas

MICU3

Calcium uptake protein 3, mitochondrial

Also known as: DKFZp313A0139, EFHA2, MICU3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XE3
Gene: MICU3
Ensembl: ENSG00000155970
Chromosome: 8
Canonical length: 530 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables calcium channel regulator activity; calcium ion sensor activity; and protein heterodimerization activity. Involved in calcium import into the mitochondrion and cellular response to calcium ion. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q86XE3|MICU3
     1  MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE RAVAEAAWRR
    61  RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS KSAATEPEDP PRGRGMLPIP
   121  VAAAKETVAI GRTDIEDLDL YATSRERRFR LFASIECEGQ LFMTPYDFIL AVTTDEPKVA
   181  KTWKSLSKQE LNQMLAETPP VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA
   241  FNMFDTDGNE MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT
   301  DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK GKAELNFEDF
   361  YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN VENTSVFLEN VRYSIPEEKG
   421  ITFDEFRSFF QFLNNLEDFA IALNMYNFAS RSIGQDEFKR AVYVATGLKF SPHLVNTVFK
   481  IFDVDKDDQL SYKEFIGIMK DRLHRGFRGY KTVQKYPTFK SCLKKELHSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICU3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 28 nTPM
cerebral cortex: 20 nTPM
retina: 14 nTPM
hippocampal formation: 11 nTPM
basal ganglia: 11 nTPM
amygdala: 10 nTPM

Single-cell type

somatotrophs: 316 nCPM
lactotrophs: 288 nCPM
pituicytes/fscs: 251 nCPM
gonadotrophs: 250 nCPM
thyrotrophs: 235 nCPM
brain excitatory neurons: 232 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 67 nTPM
cerebral cortex: 59 nTPM
white matter: 42 nTPM
basal ganglia: 39 nTPM
hippocampal formation: 37 nTPM
hypothalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICU3 as an antibody target. Whether an autoantibody or antibody against MICU3 could matter depends on whether native MICU3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICU3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICU3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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