Seroatlas · Human Serome Atlas

MICOS13

MICOS complex subunit MIC13

Also known as: C19orf70, MIC12, MIC13, MIC13_HUMAN, P117, QIL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5XKP0
Gene
MICOS13
Ensembl
ENSG00000174917
Chromosome
19
Canonical length
118 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Involved in cristae formation. Located in mitochondrial crista junction and nucleoplasm. Part of MICOS complex. Implicated in combined oxidative phosphorylation deficiency 37. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q5XKP0|MICOS13
     1  MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP AMYQFSQYVC
    61  QQTGLQIPQL PAPPKIYFPI RDSWNAGIMT VMSALSVAPS KAREYSKEGW EYVKARTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICOS13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
343 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 343 nTPM
  • skeletal muscle: 304 nTPM
  • midbrain: 207 nTPM
  • amygdala: 205 nTPM
  • cerebral cortex: 193 nTPM
  • basal ganglia: 179 nTPM

Single-cell type

  • late spermatids: 6,711 nCPM
  • early spermatids: 945 nCPM
  • esophageal suprabasal cells: 404 nCPM
  • colonocytes: 390 nCPM
  • parietal cells: 375 nCPM
  • esophageal basal cells: 357 nCPM

Immune cell

  • plasmacytoid DC: 303 nTPM
  • memory B-cell: 293 nTPM
  • total PBMC: 279 nTPM
  • intermediate monocyte: 276 nTPM
  • myeloid DC: 262 nTPM
  • non-classical monocyte: 240 nTPM

Brain region

  • hypothalamus: 134 nTPM
  • cerebellum: 131 nTPM
  • thalamus: 130 nTPM
  • medulla oblongata: 122 nTPM
  • pons: 120 nTPM
  • white matter: 115 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICOS13.

Disease | AllUniProt

Conditions MICOS13 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 37 (COXPD37) MIM:618329

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • MICOS complex subunit Mic13
  • MICOS complex subunit MIC13, QIL1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICOS13 as an antibody target. Whether an autoantibody or antibody against MICOS13 could matter depends on whether native MICOS13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICOS13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICOS13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICOS13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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