Seroatlas · Human Serome Atlas

MGAT5B

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Also known as: FLJ25132, GnT-IX, GnT-VB, MGT5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3V5L5
Gene: MGAT5B
Ensembl: ENSG00000167889
Chromosome: 17
Canonical length: 792 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Mitotic spindle

OverviewNCBI Gene

Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q3V5L5|MGAT5B
     1  MITVNPDGKI MVRRCLVTLR PFRLFVLGIG FFTLCFLMTS LGGQFSARRL GDSPFTIRTE
    61  VMGGPESRGV LRKMSDLLEL MVKRMDALAR LENSSELHRA GGDLHFPADR MPPGAGLMER
   121  IQAIAQNVSD IAVKVDQILR HSLLLHSKVS EGRRDQCEAP SDPKFPDCSG KVEWMRARWT
   181  SDPCYAFFGV DGTECSFLIY LSEVEWFCPP LPWRNQTAAQ RAPKPLPKVQ AVFRSNLSHL
   241  LDLMGSGKES LIFMKKRTKR LTAQWALAAQ RLAQKLGATQ RDQKQILVHI GFLTEESGDV
   301  FSPRVLKGGP LGEMVQWADI LTALYVLGHG LRVTVSLKEL QSNLGVPPGR GSCPLTMPLP
   361  FDLIYTDYHG LQQMKRHMGL SFKKYRCRIR VIDTFGTEPA YNHEEYATLH GYRTNWGYWN
   421  LNPKQFMTMF PHTPDNSFMG FVSEELNETE KRLIKGGKAS NMAVVYGKEA SIWKLQGKEK
   481  FLGILNKYME IHGTVYYESQ RPPEVPAFVK NHGLLPQPEF QQLLRKAKLF IGFGFPYEGP
   541  APLEAIANGC IFLQSRFSPP HSSLNHEFFR GKPTSREVFS QHPYAENFIG KPHVWTVDYN
   601  NSEEFEAAIK AIMRTQVDPY LPYEYTCEGM LERIHAYIQH QDFCRAPDPA LPEAHAPQSP
   661  FVLAPNATHL EWARNTSLAP GAWPPAHALR AWLAVPGRAC TDTCLDHGLI CEPSFFPFLN
   721  SQDAFLKLQV PCDSTESEMN HLYPAFAQPG QECYLQKEPL LFSCAGSNTK YRRLCPCRDF
   781  RKGQVALCQG CL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGAT5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 39 nTPM
basal ganglia: 13 nTPM
amygdala: 11 nTPM
hippocampal formation: 6.1 nTPM
cerebellum: 5.9 nTPM
hypothalamus: 3.3 nTPM

Single-cell type

oocytes: 74 nCPM
bergmann glia: 56 nCPM
brain inhibitory neurons: 38 nCPM
retinal amacrine cells: 31 nCPM
brain excitatory neurons: 29 nCPM
retinal ganglion cells: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 84 nTPM
basal ganglia: 58 nTPM
amygdala: 54 nTPM
thalamus: 39 nTPM
white matter: 37 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.01
gnomAD missense Z: 1.78
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGAT5B as an antibody target. Whether an autoantibody or antibody against MGAT5B could matter depends on whether native MGAT5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGAT5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MGAT5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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