MFAP3L
Microfibrillar-associated protein 3-like
Also known as: KIAA0626, MFA3L_HUMAN, NYD-sp9
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75121
- Gene
- MFAP3L
- Ensembl
- ENSG00000198948
- Chromosome
- 4
- Canonical length
- 409 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Cell Junctions
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Located in several cellular components, including cell junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
409 residues, UniProt reviewed canonical sequence.
>O75121|MFAP3L
1 MDRLKSHLTV CFLPSVPFLI LVSTLATAKS VTNSTLNGTN VVLGSVPVII ARTDHIIVKE
61 GNSALINCSV YGIPDPQFKW YNSIGKLLKE EEDEKERGGG KWQMHDSGLL NITKVSFSDR
121 GKYTCVASNI YGTVNNTVTL RVIFTSGDMG VYYMVVCLVA FTIVMVLNIT RLCMMSSHLK
181 KTEKAINEFF RTEGAEKLQK AFEIAKRIPI ITSAKTLELA KVTQFKTMEF ARYIEELARS
241 VPLPPLIMNC RTIMEEIMEV VGLEEQGQNF VRHTPEGQEA ADRDEVYTIP NSLKRSDSPA
301 ADSDASSLHE QPQQIAIKVS VHPQSKKEHA DDQEGGQFEV KDVEETELSA EHSPETAEPS
361 TDVTSTELTS EEPTPVEVPD KVLPPAYLEA TEPAVTHDKN TCIIYESHVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MFAP3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 42 nTPM
Expression across tissuesHPA
Tissue
- testis: 42 nTPM
- choroid plexus: 40 nTPM
- epididymis: 37 nTPM
- liver: 35 nTPM
- kidney: 28 nTPM
- basal ganglia: 26 nTPM
Single-cell type
- late spermatids: 3,095 nCPM
- retinal pigment epithelial cells: 588 nCPM
- early spermatids: 538 nCPM
- platelets: 399 nCPM
- choroid plexus epithelial cells: 205 nCPM
- astrocytes: 162 nCPM
Immune cell
- basophil: 5.7 nTPM
- total PBMC: 4.7 nTPM
- neutrophil: 3.5 nTPM
- eosinophil: 1.8 nTPM
- intermediate monocyte: 0.7 nTPM
- gdT-cell: 0.6 nTPM
Brain region
- choroid plexus: 202 nTPM
- white matter: 145 nTPM
- basal ganglia: 139 nTPM
- midbrain: 136 nTPM
- thalamus: 128 nTPM
- pons: 119 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.88
- gnomAD missense Z
- 1.42
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MFAP3L as an antibody target. Whether an autoantibody or antibody against MFAP3L could matter depends on whether native MFAP3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MFAP3L is annotated at the cell surface, where native MFAP3L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MFAP3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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