Seroatlas · Human Serome Atlas

MFAP3

Microfibril-associated glycoprotein 3

Also known as: MFAP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55082
Gene: MFAP3
Ensembl: ENSG00000037749
Chromosome: 5
Canonical length: 362 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>P55082|MFAP3
     1  MKLHCCLFTL VASIIVPAAF VLEDVDFDQM VSLEANRSSY NASFPSSFEL SASSHSDDDV
    61  IIAKEGTSVS IECLLTASHY EDVHWHNSKG QQLDGRSRGG KWLVSDNFLN ITNVAFDDRG
   121  LYTCFVTSPI RASYSVTLRV IFTSGDMSVY YMIVCLIAFT ITLILNVTRL CMMSSHLRKT
   181  EKAINEFFRT EGAEKLQKAF EIAKRIPIIT SAKTLELAKV TQFKTMEFAR YIEELARSVP
   241  LPPLILNCRA FVEEMFEAVR VDDPDDLGER IKERPALNAQ GGIYVINPEM GRSNSPGGDS
   301  DDGSLNEQGQ EIAVQVSVHL QSETKSIDTE SQGSSHFSPP DDIGSAESNC NYKDGAYENC
   361  QL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 23 nTPM
placenta: 18 nTPM
tongue: 16 nTPM
smooth muscle: 16 nTPM
urinary bladder: 15 nTPM
adipose tissue: 15 nTPM

Single-cell type

myonuclei: 61 nCPM
tuft cells: 58 nCPM
astrocytes: 55 nCPM
brain inhibitory neurons: 52 nCPM
müller glia: 52 nCPM
brain excitatory neurons: 51 nCPM

Immune cell

eosinophil: 12 nTPM
myeloid DC: 8.1 nTPM
intermediate monocyte: 7.9 nTPM
classical monocyte: 7.6 nTPM
MAIT T-cell: 6.9 nTPM
basophil: 6.8 nTPM

Brain region

choroid plexus: 24 nTPM
cerebellum: 20 nTPM
spinal cord: 17 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFAP3 as an antibody target. Whether an autoantibody or antibody against MFAP3 could matter depends on whether native MFAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFAP3 is annotated at the cell surface, where native MFAP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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