Seroatlas · Human Serome Atlas

MFAP2

Microfibrillar-associated protein 2

Also known as: MAGP, MAGP-1, MFAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55001
Gene: MFAP2
Ensembl: ENSG00000117122
Chromosome: 1
Canonical length: 183 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P55001|MFAP2
     1  MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY QEVTPRPSEE
    61  QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE QYPCTRLYSI HRPCKQCLNE
   121  VCFYSLRRVY VINKEICVRT VCAHEELLRA DLCRDKFSKC GVMASSGLCQ SVAASCARSC
   181  GSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

cervix: 89 nTPM
gallbladder: 69 nTPM
ovary: 64 nTPM
blood vessel: 59 nTPM
endometrium: 57 nTPM
placenta: 40 nTPM

Single-cell type

extravillous trophoblasts: 3.1 nCPM
lymphatic endothelial cells: 3.1 nCPM
melanocytes: 3 nCPM
late spermatids: 2.5 nCPM
cardiomyocytes: 2.4 nCPM
fibroblasts: 2.4 nCPM

Immune cell

gdT-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3 nTPM
midbrain: 1.6 nTPM
medulla oblongata: 1.2 nTPM
cerebral cortex: 1.1 nTPM
thalamus: 1.1 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MFAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFAP2 as an antibody target. Whether an autoantibody or antibody against MFAP2 could matter depends on whether native MFAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFAP2 is annotated as secreted, so native MFAP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MFAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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