Seroatlas · Human Serome Atlas

METTL8

tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial

Also known as: METL8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H825
Gene: METTL8
Canonical length: 291 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for METTL8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9H825|METTL8
     1  MNMIWRNSIS CLRLGKVPHR YQSGYHPVAP LGSRILTDPA KVFEHNMWDH MQWSKEEEAA
    61  ARKKVKENSA VRVLLEEQVK YEREASKYWD TFYKIHKNKF FKDRNWLLRE FPEILPVDQK
   121  PEEKARESSW DHVKTSATNR FSRMHCPTVP DEKNHYEKSS GSSEGQSKTE SDFSNLDSEK
   181  HKKGPMETGL FPGSNATFRI LEVGCGAGNS VFPILNTLEN SPESFLYCCD FASGAVELVK
   241  SHSSYRATQC FAFVHDVCDD GLPYPFPDGI LDVILLVFVL SSIHPDRTLF I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

esophagus: 8.1 nTPM
smooth muscle: 6.2 nTPM
skin: 5.9 nTPM
colon: 5 nTPM
urinary bladder: 5 nTPM
rectum: 4.9 nTPM

Single-cell type

cardiomyocytes: 87 nCPM
esophageal basal cells: 80 nCPM
basal keratinocytes: 79 nCPM
fibro-adipogenic progenitors: 76 nCPM
adipocytes: 72 nCPM
sertoli cells: 67 nCPM

Immune cell

plasmacytoid DC: 6.8 nTPM
naive B-cell: 5.2 nTPM
T-reg: 4.8 nTPM
memory CD4 T-cell: 4.5 nTPM
MAIT T-cell: 4.4 nTPM
NK-cell: 3.7 nTPM

Brain region

basal ganglia: 17 nTPM
white matter: 14 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 14 nTPM
thalamus: 14 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tRNA (cytidine-3-)-methyltransferase activity
mRNA methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EP300

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL8 as an antibody target. Whether an autoantibody or antibody against METTL8 could matter depends on whether native METTL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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