Seroatlas · Human Serome Atlas

METTL5

rRNA N(6)-adenosine-methyltransferase METTL5

Also known as: HSPC133, METL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRN9
Gene: METTL5
Ensembl: ENSG00000138382
Chromosome: 2
Canonical length: 209 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation and rRNA methylation. Located in several cellular components, including fibrillar center; postsynapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 72. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q9NRN9|METTL5
     1  MKKVRLKELE SRLQQVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI ENKVVADLGC
    61  GCGVLSIGTA MLGAGLCVGF DIDEDALEIF NRNAEEFELT NIDMVQCDVC LLSNRMSKSF
   121  DTVIMNPPFG TKNNKGTDMA FLKTALEMAR TAVYSLHKSS TREHVQKKAA EWKIKIDIIA
   181  ELRYDLPASY KFHKKKSVDI EVDLIRFSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 87 nTPM
tongue: 69 nTPM
blood vessel: 67 nTPM
heart muscle: 61 nTPM
epididymis: 59 nTPM
pancreas: 51 nTPM

Single-cell type

esophageal basal cells: 179 nCPM
gastric progenitor cells: 160 nCPM
esophageal suprabasal cells: 157 nCPM
parietal cells: 156 nCPM
extravillous trophoblasts: 150 nCPM
megakaryocytes: 148 nCPM

Immune cell

memory B-cell: 65 nTPM
MAIT T-cell: 62 nTPM
T-reg: 58 nTPM
naive CD4 T-cell: 57 nTPM
naive B-cell: 57 nTPM
memory CD4 T-cell: 55 nTPM

Brain region

hypothalamus: 39 nTPM
white matter: 37 nTPM
spinal cord: 35 nTPM
cerebral cortex: 33 nTPM
midbrain: 33 nTPM
medulla oblongata: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about METTL5.

Disease | AllUniProt

Conditions METTL5 is implicated in, by any mechanism.

Intellectual developmental disorder, autosomal recessive 72 (MRT72) MIM:618665

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 71 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, autosomal recessive 72
Severe intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DNA methylase, N-6 adenine-specific, conserved site
Methyltransferase small domain
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Methyltransferase small domain
rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL5 as an antibody target. Whether an autoantibody or antibody against METTL5 could matter depends on whether native METTL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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