Seroatlas · Human Serome Atlas

METTL2B

tRNA N(3)-cytidine methyltransferase METTL2B

Also known as: FLJ11350, MET2B_HUMAN, METL, METTL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1Q9
Gene
METTL2B
Ensembl
ENSG00000165055
Chromosome
7
Canonical length
378 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q6P1Q9|METTL2B
     1  MAGSYPEGAP AILADKRQQF GSRFLSDPAR VFHHNAWDNV EWSEEQAAAA ERKVQENSIQ
    61  RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF PELAPSQNQN HLKDWFLENK
   121  SEVCECRNNE DGPGLIMEEQ HKCSSKSLEH KTQTPPVEEN VTQKISDLEI CADEFPGSSA
   181  TYRILEVGCG VGNTVFPILQ TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL
   241  CDEEKSYPVP KGSLDIIILI FVLSAVVPDK MQKAINRLSR LLKPGGMVLL RDYGRYDMAQ
   301  LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL QVNRGKQLTM
   361  YRVWIQCKYC KPLLSSTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
7.7 nTPM

Expression across tissuesHPA

Tissue

  • liver: 7.7 nTPM
  • skin: 7.4 nTPM
  • skeletal muscle: 6.5 nTPM
  • cerebral cortex: 5.8 nTPM
  • retina: 5.8 nTPM
  • hypothalamus: 5.7 nTPM

Single-cell type

  • choroid plexus epithelial cells: 43 nCPM
  • podocytes: 40 nCPM
  • renal collecting duct intercalated cells: 39 nCPM
  • distal convoluted tubule cells: 35 nCPM
  • adipocytes: 34 nCPM
  • renal connecting tubule cells: 34 nCPM

Immune cell

  • basophil: 2.7 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • gdT-cell: 2.1 nTPM
  • naive B-cell: 2.1 nTPM
  • memory CD4 T-cell: 1.9 nTPM
  • naive CD4 T-cell: 1.9 nTPM

Brain region

  • cerebellum: 22 nTPM
  • white matter: 21 nTPM
  • hypothalamus: 19 nTPM
  • thalamus: 19 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL2B as an antibody target. Whether an autoantibody or antibody against METTL2B could matter depends on whether native METTL2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/METTL2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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