METTL26
Methyltransferase-like 26
Also known as: C16orf13, MGC13114, MTL26_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96S19
- Gene
- METTL26
- Ensembl
- ENSG00000130731
- Chromosome
- 16
- Canonical length
- 204 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
No narrative summary is available for METTL26 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
204 residues, UniProt reviewed canonical sequence.
>Q96S19|METTL26
1 MLVAAAAERN KDPILHVLRQ YLDPAQRGVR VLEVASGSGQ HAAHFARAFP LAEWQPSDVD
61 QRCLDSIAAT TQAQGLTNVK APLHLDVTWG WEHWGGILPQ SLDLLLCINM AHVSPLRCTE
121 GLFRAAGHLL KPRALLITYG PYAINGKISP QSNVDFDLML RCRNPEWGLR DTALLEDLGK
181 ASGLLLERMV DMPANNKCLI FRKNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against METTL26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 140 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 140 nTPM
- cerebral cortex: 129 nTPM
- basal ganglia: 129 nTPM
- hippocampal formation: 116 nTPM
- cerebellum: 93 nTPM
- skeletal muscle: 89 nTPM
Single-cell type
- late spermatids: 777 nCPM
- gastric progenitor cells: 246 nCPM
- extravillous trophoblasts: 244 nCPM
- epididymal principal cells: 198 nCPM
- esophageal basal cells: 189 nCPM
- migrating cytotrophoblasts: 174 nCPM
Immune cell
- non-classical monocyte: 169 nTPM
- plasmacytoid DC: 163 nTPM
- T-reg: 161 nTPM
- myeloid DC: 151 nTPM
- memory B-cell: 146 nTPM
- intermediate monocyte: 146 nTPM
Brain region
- cerebral cortex: 76 nTPM
- basal ganglia: 69 nTPM
- hippocampal formation: 67 nTPM
- thalamus: 65 nTPM
- amygdala: 63 nTPM
- white matter: 62 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Protein of unknown function DUF938
- Protein of unknown function (DUF938)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads METTL26 as an antibody target. Whether an autoantibody or antibody against METTL26 could matter depends on whether native METTL26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
METTL26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label METTL26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...