Seroatlas · Human Serome Atlas

METTL25

Probable methyltransferase-like protein 25

Also known as: C12orf26, FLJ22789, MET25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6Q8
Gene: METTL25
Ensembl: ENSG00000127720
Chromosome: 12
Canonical length: 603 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q8N6Q8|METTL25
     1  MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL VDLPPETVLA
    61  ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ KLVSVEAFAL AAKYYSVQNL
   121  GICTPFEQLL VALRGNQNQR IGENQKAVEF MNMKKSHEVQ AMSELISSIA DYYGIKQVID
   181  LGSGKGYLSS FLSLKYGLKV YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL
   241  KMAKERKVQN KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP
   301  HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS SESNIYSPLT
   361  SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS NSEIKGVCSV GCCYHLLSEE
   421  FENQHKERTQ EKWGFPMCHY LKEERWCCGR NARMSACLAL ERVAAGQGLP TESLFYRAVL
   481  QDIIKDCYGI TKCDRHVGKI YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR
   541  MNELEAFNML KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK
   601  KQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

retina: 5.6 nTPM
testis: 5.5 nTPM
breast: 5.4 nTPM
ovary: 4.8 nTPM
heart muscle: 4.4 nTPM
lymph node: 4.4 nTPM

Single-cell type

corticotrophs: 201 nCPM
thyrotrophs: 162 nCPM
myonuclei: 161 nCPM
lactotrophs: 151 nCPM
choroid plexus epithelial cells: 149 nCPM
somatotrophs: 141 nCPM

Immune cell

basophil: 19 nTPM
neutrophil: 12 nTPM
plasmacytoid DC: 11 nTPM
NK-cell: 10 nTPM
naive B-cell: 7.3 nTPM
classical monocyte: 6.5 nTPM

Brain region

cerebral cortex: 87 nTPM
white matter: 69 nTPM
pons: 68 nTPM
medulla oblongata: 65 nTPM
thalamus: 55 nTPM
hypothalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -1.19
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

methylation

Molecular functions

methyltransferase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL25 as an antibody target. Whether an autoantibody or antibody against METTL25 could matter depends on whether native METTL25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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