Seroatlas · Human Serome Atlas

METTL24

Probable methyltransferase-like protein 24

Also known as: C6orf186, dJ71D21.2, MET24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JXM2
Gene: METTL24
Ensembl: ENSG00000053328
Chromosome: 6
Canonical length: 366 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q5JXM2|METTL24
     1  MARERPPGRG CGVLRRCLLG AVLLFGLRLC AELRRAGPGS PTRSAPPGPA WRPPGPHLPP
    61  APGQPRGASR RQVTYVRSGR RAPPGGGGSG TPEPGCCAPR GRPRRKGPRW HIDLQPWAGS
   121  AQSLDEEAWR FLRYISTTQI ACNHMNTDSL ATDSSPTHKP WSVCLDDRFN LAHQIRNKQC
   181  RLYSLGLGSD DTHFEVSMAN NGCEVHRFDP SVKSAHILES QHLWYHRLSI DWRDPHPAVA
   241  AQKPHSNTRK LGSILNEFGH HKIDVLKADL ESAEWKVLEN LILEDVLEQI GQLIFEIHLH
   301  WPGFEVSGSD SSVVRFWYSL LKELEQKDFR LFHSYKDLSK PQLFLKKDIF NASSCYTLSW
   361  VNTRWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 11 nTPM
colon: 9.5 nTPM
blood vessel: 7 nTPM
endometrium: 6.6 nTPM
seminal vesicle: 6.2 nTPM
ovary: 4.8 nTPM

Single-cell type

choroid plexus epithelial cells: 189 nCPM
pituitary stem cells: 183 nCPM
gonadotrophs: 82 nCPM
podocytes: 80 nCPM
retinal horizontal cells: 70 nCPM
lactotrophs: 67 nCPM

Immune cell

MAIT T-cell: 2.4 nTPM
memory CD8 T-cell: 0.5 nTPM
T-reg: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

choroid plexus: 18 nTPM
cerebellum: 13 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 12 nTPM
hippocampal formation: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Methyltransferase domain
Probable methyltransferase-like protein 24
Methyltransferase domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL24 as an antibody target. Whether an autoantibody or antibody against METTL24 could matter depends on whether native METTL24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL24 is annotated as secreted, so native METTL24 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label METTL24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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