Seroatlas · Human Serome Atlas

METTL21EP

Putative methyltransferase-like protein 21E pseudogene

Also known as: MT21E_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDL7
Gene: METTL21EP
Canonical length: 271 aa

OverviewNCBI Gene

No narrative summary is available for METTL21EP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>A6NDL7|METTL21EP
     1  MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD KQVVTEIMAR
    61  CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL VLCYFLETNA KQYNMVDKNV
   121  IEIGAGTGLV SIVASLLGAH VTATDLPELL GNLQYNISRN TKMKSKHLPQ VKELSWGVAL
   181  DTNFPRSSNN FDYILAADVV YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR
   241  FKELFDLEEI SSFPSLNIKL YKAVKKNRRS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL21EP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL21EP as an antibody target. Whether an autoantibody or antibody against METTL21EP could matter depends on whether native METTL21EP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL21EP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL21EP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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