Seroatlas · Human Serome Atlas

METTL21C

Protein-lysine methyltransferase METTL21C

Also known as: C13orf39, LOC196541, MT21C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZV1
Gene: METTL21C
Ensembl: ENSG00000139780
Chromosome: 13
Canonical length: 264 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q5VZV1|METTL21C
     1  MDVCLSSAQQ PGRRGEGLSS PGGWLEAEKK GAPQKDSTGG VLEESNKIEP SLHSLQKFVP
    61  TDYASYTQEH YRFAGKEIVI QESIESYGAV VWPGAMALCQ YLEEHAEELN FQDAKILEIG
   121  AGPGLVSIVA SILGAQVTAT DLPDVLGNLQ YNLLKNTLQC TAHLPEVKEL VWGEDLDKNF
   181  PKSAFYYDYV LASDVVYHHY FLDKLLTTMV YLSQPGTVLL WANKFRFSTD YEFLDKFKQV
   241  FDTTLLAEYP ESSVKLFKGI LKWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL21C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

epididymis: 23 nTPM
skeletal muscle: 4 nTPM
seminal vesicle: 1.3 nTPM
placenta: 1 nTPM
cerebral cortex: 0.8 nTPM
prostate: 0.6 nTPM

Single-cell type

epididymal principal cells: 28 nCPM
late spermatids: 7.8 nCPM
retinal ganglion cells: 7.7 nCPM
myonuclei: 6.8 nCPM
cytotrophoblasts: 4.8 nCPM
early spermatids: 3.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 4.9 nTPM
cerebellum: 4.6 nTPM
choroid plexus: 3.2 nTPM
white matter: 3 nTPM
hippocampal formation: 2.8 nTPM
basal ganglia: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL21C as an antibody target. Whether an autoantibody or antibody against METTL21C could matter depends on whether native METTL21C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL21C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL21C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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