Seroatlas · Human Serome Atlas

METRN

Meteorin

Also known as: C16orf23, METRN_HUMAN, MGC2601

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJH8
Gene: METRN
Ensembl: ENSG00000103260
Chromosome: 16
Canonical length: 293 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Cytosol
Secretome location: Secreted in brain

OverviewNCBI Gene

Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q9UJH8|METRN
     1  MGFPAAALLC ALCCGLLAPA ARAGYSEERC SWRGSGLTQE PGSVGQLALA CAEGAVEWLY
    61  PAGALRLTLG GPDPRARPGI ACLRPVRPFA GAQVFAERAG GALELLLAEG PGPAGGRCVR
   121  WGPRERRALF LQATPHQDIS RRVAAFRFEL REDGRPELPP QAHGLGVDGA CRPCSDAELL
   181  LAACTSDFVI HGIIHGVTHD VELQESVITV VAARVLRQTP PLFQAGRSGD QGLTSIRTPL
   241  RCGVHPGPGT FLFMGWSRFG EARLGCAPRF QEFRRAYEAA RAAHLHPCEV ALH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 390 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 390 nTPM
midbrain: 318 nTPM
amygdala: 307 nTPM
spinal cord: 289 nTPM
hippocampal formation: 275 nTPM
cerebral cortex: 252 nTPM

Single-cell type

fallopian tube ciliated cells: 690 nCPM
müller glia: 595 nCPM
ependymal cells: 451 nCPM
respiratory ciliated cells: 346 nCPM
bergmann glia: 318 nCPM
epididymal efferent duct ciliated cells: 311 nCPM

Immune cell

memory B-cell: 1.3 nTPM
T-reg: 1 nTPM
gdT-cell: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM
MAIT T-cell: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

thalamus: 335 nTPM
medulla oblongata: 329 nTPM
spinal cord: 303 nTPM
midbrain: 293 nTPM
amygdala: 286 nTPM
choroid plexus: 285 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0.09
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Meteorin-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METRN as an antibody target. Whether an autoantibody or antibody against METRN could matter depends on whether native METRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METRN is annotated as secreted, so native METRN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label METRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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