Seroatlas · Human Serome Atlas

MESP1

Mesoderm posterior protein 1

Also known as: bHLHc5, MESP1_HUMAN, MGC10676

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRJ9
Gene
MESP1
Ensembl
ENSG00000166823
Chromosome
15
Canonical length
268 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including endothelial cell differentiation; heart development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Implicated in myocardial infarction. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>Q9BRJ9|MESP1
     1  MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT
    61  LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL
   121  TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA
   181  EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS
   241  PLLPGDVLAL LETWMPLSPL EWLPEEPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MESP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 21 nTPM
  • amygdala: 15 nTPM
  • cerebral cortex: 14 nTPM
  • skeletal muscle: 13 nTPM
  • hypothalamus: 12 nTPM
  • hippocampal formation: 11 nTPM

Single-cell type

  • oocytes: 170 nCPM
  • breast secretory cells: 100 nCPM
  • prostatic glandular cells: 76 nCPM
  • breast lactating cells: 65 nCPM
  • respiratory secretory cells: 61 nCPM
  • salivary duct cells: 56 nCPM

Immune cell

  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • basal ganglia: 17 nTPM
  • hypothalamus: 15 nTPM
  • hippocampal formation: 15 nTPM
  • amygdala: 14 nTPM
  • white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MESP1 as an antibody target. Whether an autoantibody or antibody against MESP1 could matter depends on whether native MESP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MESP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MESP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MESP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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