Seroatlas · Human Serome Atlas

MESD

LRP chaperone MESD

Also known as: BOCA, KIAA0081, MESD_HUMAN, MESDC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14696
Gene
MESD
Ensembl
ENSG00000117899
Chromosome
15
Canonical length
234 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Endoplasmic reticulum,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to enable low-density lipoprotein particle receptor binding activity and protein folding chaperone. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q14696|MESD
     1  MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK KKKDIRDYND
    61  ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK PESILKMTKK GKTLMMFVTV
   121  SGSPTEKETE EITSLWQGSL FNANYDVQRF IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC
   181  ADVTLEGQVY PGKGGGSKEK NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MESD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 40 nTPM
  • thyroid gland: 32 nTPM
  • choroid plexus: 27 nTPM
  • placenta: 25 nTPM
  • liver: 20 nTPM
  • spinal cord: 19 nTPM

Single-cell type

  • syncytiotrophoblasts: 530 nCPM
  • cytotrophoblasts: 411 nCPM
  • epididymal principal cells: 384 nCPM
  • migrating cytotrophoblasts: 345 nCPM
  • extravillous trophoblasts: 337 nCPM
  • esophageal apical cells: 228 nCPM

Immune cell

  • plasmacytoid DC: 45 nTPM
  • NK-cell: 45 nTPM
  • T-reg: 43 nTPM
  • MAIT T-cell: 42 nTPM
  • basophil: 40 nTPM
  • memory CD4 T-cell: 37 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebellum: 17 nTPM
  • basal ganglia: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MESD.

Disease | AllUniProt

Conditions MESD is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 110 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Osteogenesis imperfecta, type 20

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.63
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • LRP chaperone MESD
  • Chaperone for wingless signalling and trafficking of LDL receptor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MESD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MESD as an antibody target. Whether an autoantibody or antibody against MESD could matter depends on whether native MESD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MESD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MESD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MESD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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