MEOX1

Protein identityUniProt · HPA

UniProt accession

P50221

Gene

MEOX1

Ensembl

ENSG00000005102

Chromosome

17

Canonical length

254 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>P50221|MEOX1
     1  MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD FLATATAAYP
    61  DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSD ARRRPNSGPA GGSKEMGTSS
   121  LGLVDTTGGP GDDYGVLGST ANETEKKSSR RRKESSDNQE NRGKPEGSSK ARKERTAFTK
   181  EQLRELEAEF AHHNYLTRLR RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPISPNGQ
   241  DPEDGDSTAS PSSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEOX1.

Disease | AllUniProt

Conditions MEOX1 is implicated in, by any mechanism.

• Klippel-Feil syndrome 2, autosomal recessive (KFS2) MIM:214300

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 132 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Klippel-Feil syndrome 2, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

gnomAD missense Z

-0.26

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• hematopoietic stem cell differentiation
• regulation of transcription by RNA polymerase II
• sclerotome development
• somite development
• somite specification

Molecular functions

• chromatin binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• HMG box domain binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• Homeobox protein MOX-1/MOX-2
• Homeodomain

KeywordsUniProt

• Activator
• Cytoplasm
• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of MEOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PAX1