Seroatlas · Human Serome Atlas

MENT

Protein MENT

Also known as: C1orf56, FLJ20519, MENT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUN1
Gene: MENT
Ensembl: ENSG00000143443
Chromosome: 1
Canonical length: 341 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is a proto-oncogene whose promoter is methylated by DNA methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q9BUN1|MENT
     1  MVPAAGALLW VLLLNLGPRA AGAQGLTQTP TEMQRVSLRF GGPMTRSYRS TARTGLPRKT
    61  RIILEDENDA MADADRLAGP AAAELLAATV STGFSRSSAI NEEDGSSEEG VVINAGKDST
   121  SRELPSATPN TAGSSSTRFI ANSQEPEIRL TSSLPRSPGR STEDLPGSQA TLSQWSTPGS
   181  TPSRWPSPSP TAMPSPEDLR LVLMPWGPWH CHCKSGTMSR SRSGKLHGLS GRLRVGALSQ
   241  LRTEHKPCTY QQCPCNRLRE ECPLDTSLCT DTNCASQSTT STRTTTTPFP TIHLRSSPSL
   301  PPASPCPALA FWKRVRIGLE DIWNSLSSVF TEMQPIDRNQ R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MENT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

testis: 72 nTPM
adrenal gland: 9.8 nTPM
pituitary gland: 9.5 nTPM
liver: 8 nTPM
thyroid gland: 7.9 nTPM
heart muscle: 7.5 nTPM

Single-cell type

late primary spermatocytes: 751 nCPM
early spermatids: 412 nCPM
esophageal apical cells: 149 nCPM
nk-cells: 133 nCPM
microglia: 119 nCPM
epicardial cells: 118 nCPM

Immune cell

basophil: 225 nTPM
naive CD8 T-cell: 91 nTPM
gdT-cell: 91 nTPM
memory CD8 T-cell: 81 nTPM
memory CD4 T-cell: 79 nTPM
MAIT T-cell: 70 nTPM

Brain region

cerebellum: 8.7 nTPM
choroid plexus: 8.4 nTPM
white matter: 8.3 nTPM
medulla oblongata: 8 nTPM
spinal cord: 7.9 nTPM
basal ganglia: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell population proliferation

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Methylated in normal thymocytes protein
Protein missing in infertile sperm 1, putative

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MENT as an antibody target. Whether an autoantibody or antibody against MENT could matter depends on whether native MENT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MENT is annotated as secreted, so native MENT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MENT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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