Seroatlas · Human Serome Atlas

MEMO1

Protein MEMO1

Also known as: C2orf4, CGI-27, MEMO, MEMO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y316
Gene: MEMO1
Ensembl: ENSG00000162959
Chromosome: 2
Canonical length: 297 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q9Y316|MEMO1
     1  MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA
    61  HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE
   121  RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP
   181  SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
   241  NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
skeletal muscle: 54 nTPM
bone marrow: 43 nTPM
heart muscle: 34 nTPM
tongue: 34 nTPM
liver: 34 nTPM

Single-cell type

microglia: 409 nCPM
brain excitatory neurons: 177 nCPM
other brain neurons: 175 nCPM
brain inhibitory neurons: 174 nCPM
oligodendrocytes: 169 nCPM
oligodendrocyte progenitor cells: 160 nCPM

Immune cell

non-classical monocyte: 28 nTPM
myeloid DC: 24 nTPM
intermediate monocyte: 23 nTPM
T-reg: 17 nTPM
eosinophil: 17 nTPM
classical monocyte: 17 nTPM

Brain region

white matter: 43 nTPM
amygdala: 40 nTPM
midbrain: 39 nTPM
thalamus: 39 nTPM
medulla oblongata: 39 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 2.64
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of microtubule-based process

Cellular components

Protein domainsUniProt · Pfam · InterPro

MEMO1 family
Memo-like protein

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEMO1 as an antibody target. Whether an autoantibody or antibody against MEMO1 could matter depends on whether native MEMO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEMO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEMO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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