Seroatlas · Human Serome Atlas

MELTF

Melanotransferrin

Also known as: CD228, FLJ38863, MAP97, MFI2, MGC4856, MTf, MTF1, TRFM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08582
Gene
MELTF
Ensembl
ENSG00000163975
Chromosome
3
Canonical length
738 aa
Protein class
CD markers, Plasma proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>P08582|MELTF
     1  MRGPSGALWL LLALRTVLGG MEVRWCATSD PEQHKCGNMS EAFREAGIQP SLLCVRGTSA
    61  DHCVQLIAAQ EADAITLDGG AIYEAGKEHG LKPVVGEVYD QEVGTSYYAV AVVRRSSHVT
   121  IDTLKGVKSC HTGINRTVGW NVPVGYLVES GRLSVMGCDV LKAVSDYFGG SCVPGAGETS
   181  YSESLCRLCR GDSSGEGVCD KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGKT
   241  LPSWGQALLS QDFELLCRDG SRADVTEWRQ CHLARVPAHA VVVRADTDGG LIFRLLNEGQ
   301  RLFSHEGSSF QMFSSEAYGQ KDLLFKDSTS ELVPIATQTY EAWLGHEYLH AMKGLLCDPN
   361  RLPPYLRWCV LSTPEIQKCG DMAVAFRRQR LKPEIQCVSA KSPQHCMERI QAEQVDAVTL
   421  SGEDIYTAGK TYGLVPAAGE HYAPEDSSNS YYVVAVVRRD SSHAFTLDEL RGKRSCHAGF
   481  GSPAGWDVPV GALIQRGFIR PKDCDVLTAV SEFFNASCVP VNNPKNYPSS LCALCVGDEQ
   541  GRNKCVGNSQ ERYYGYRGAF RCLVENAGDV AFVRHTTVFD NTNGHNSEPW AAELRSEDYE
   601  LLCPNGARAE VSQFAACNLA QIPPHAVMVR PDTNIFTVYG LLDKAQDLFG DDHNKNGFKM
   661  FDSSNYHGQD LLFKDATVRA VPVGEKTTYR GWLGLDYVAA LEGMSSQQCS GAAAPAPGAP
   721  LLPLLLPALA ARLLPPAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MELTF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 67 nTPM
  • kidney: 38 nTPM
  • choroid plexus: 25 nTPM
  • skin: 16 nTPM
  • parathyroid gland: 10 nTPM
  • small intestine: 9.5 nTPM

Single-cell type

  • lacrimal acinar cells: 125 nCPM
  • mast cells: 104 nCPM
  • salivary acinar cells: 70 nCPM
  • epicardial cells: 66 nCPM
  • breast secretory cells: 56 nCPM
  • respiratory deuterosomal cells: 54 nCPM

Immune cell

  • MAIT T-cell: 0.8 nTPM
  • non-classical monocyte: 0.6 nTPM
  • myeloid DC: 0.5 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • thalamus: 19 nTPM
  • cerebral cortex: 12 nTPM
  • midbrain: 11 nTPM
  • amygdala: 9.7 nTPM
  • cerebellum: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MELTF as an antibody target. Whether an autoantibody or antibody against MELTF could matter depends on whether native MELTF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MELTF is annotated at the cell surface, where native MELTF is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MELTF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MELTF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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