Seroatlas · Human Serome Atlas

MEI1

Meiosis inhibitor protein 1

Also known as: MEI1_HUMAN, MGC40042, SPATA38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TIA1
Gene: MEI1
Ensembl: ENSG00000167077
Chromosome: 22
Canonical length: 1274 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in meiosis I. Predicted to act upstream of or within germ cell development; meiotic nuclear division; and meiotic spindle organization. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1274 residues, UniProt reviewed canonical sequence.

>Q5TIA1|MEI1
     1  MAVRQAATAG TPGPRREEEA ALLFERAHYR HDPRWLLPVT PRLCLACALE LLPDPGVSLV
    61  RKKHMLSCFQ DALVRHTSLV TQLVSQDQRV CIHFISVLFG LLCSMEDGSV TDLCIEVLIQ
   121  ITTQLKLEQT IRCLLDECHK ELCNMPSMRG SLATLTLLGK LVDAIPALAD ELVMEHGNLM
   181  EHLLRGLVYP SEGIQASVCY LYGKLYSSPV AAEMLSGHFR EKLFPLFLSI LDGAQTKELQ
   241  INCLGLLRQL LKYDLFVSMI MNQDGLGESA KNIEGSSGNT SLPLVLKKLL LSRDETLQVA
   301  SAHCITAVLV HSPAKHASAF IHADIPEFLF EHLSSSSEVL VWSSCNCLTL LVEEPLFFSK
   361  CHTVYGIEAV VRSLQGSLKM NNIELHKQGL LLFAEILTRQ PEEIKLFTSS AMCRDAGRAL
   421  QEAVSSPVLE VAAEALKATS AFLRKDHQST PPVQYGELQA LLEAMLNRCA EFSQTLLSRR
   481  PLGHASSRDS EKAILQRGKF LLSTLEGFRS ACRLAIEFQS EPSAQENPFT APSAKKEDTL
   541  EAFSEFLLSA CDSLCIPMVM RHLEQTTHPA LMEVFLSILH NLFVIVPHMK EKFSKKLASS
   601  SFIRLTLELK ARFCSGLSHS ALNQVCSNFL YYMCLNLLSA PEKTGPPSKE ELSAVSELLQ
   661  HGLPQISSRS PESLAFLSDR QYMEGAARQR QYCILLLFYL AYIHEDRFVS EAELFEAVQS
   721  FLLSLQDQGE RPPLVVFKAS IYLLAICQDK DNTLRETMVS AIRKFLEGIP DLQLVYTHHP
   781  LLLRFFLLYP ELMSRYGHRV LELWFFWEES SYEELDDVTS AGQPALPASL VVLFQLLRSI
   841  PSILLILLDL IYSSPVDTAH KVLISLRTFL RRNEDIQVGG LIRGHFLLIL QRLLVEHGAS
   901  PSGASGNLPL LLSLLSLMQL RNVSEQELDS VAMKLLHQVS KLCGKCSPTD VDILQPSFNF
   961  LYWSLHQTTP SSQKRAAAVL LSSTGLMELL EKMLALTLAK ADSPRTALLC SAWLLTASFS
  1021  AQQHKGSLQV HQTLSVEMDQ VLKALSFPKK KAALLSAAIL CFLRTALRQS FSSALVALVP
  1081  SGAQPLPATK DTVLAPLRMS QVRSLVIGLQ NLLVQKDPLL SQACVGCLEA LLDYLDARSP
  1141  DIALHVASQP WNRFLLFTLL DAGENSFLRP EILRLMTLFM RYRSSSVLSH EEVGDVLQGV
  1201  ALADLSTLSN TTLQALHGFF QQLQSMGHLA DHSMAQTLQA SLEGLPPSTS SGQPPLQDML
  1261  CLGGVAVSLS HIRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

testis: 37 nTPM
spleen: 21 nTPM
bone marrow: 11 nTPM
small intestine: 7.8 nTPM
tonsil: 7.5 nTPM
salivary gland: 6.5 nTPM

Single-cell type

early primary spermatocytes: 297 nCPM
plasma cells: 220 nCPM
differentiating spermatogonia: 126 nCPM
early spermatids: 97 nCPM
late spermatids: 75 nCPM
neutrophils: 46 nCPM

Immune cell

T-reg: 57 nTPM
memory CD4 T-cell: 30 nTPM
gdT-cell: 30 nTPM
MAIT T-cell: 29 nTPM
memory CD8 T-cell: 26 nTPM
naive CD8 T-cell: 24 nTPM

Brain region

thalamus: 7.3 nTPM
cerebral cortex: 5.4 nTPM
midbrain: 4 nTPM
white matter: 2.5 nTPM
medulla oblongata: 2.2 nTPM
pons: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEI1.

Disease | AllUniProt

Conditions MEI1 is implicated in, by any mechanism.

Hydatidiform mole, recurrent, 3 (HYDM3) MIM:618431

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 249 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hydatidiform mole, recurrent, 3
OOCYTE/ZYGOTE/EMBRYO MATURATION ARREST 26
SPERMATOGENIC FAILURE 103
MEI1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

meiosis I

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Meiosis

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEI1 as an antibody target. Whether an autoantibody or antibody against MEI1 could matter depends on whether native MEI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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