Seroatlas · Human Serome Atlas

MEDAG

Mesenteric estrogen-dependent adipogenesis protein

Also known as: AWMS3, C13orf33, FLJ14834, MEDA-4, MEDAG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYS4
Gene: MEDAG
Ensembl: ENSG00000102802
Chromosome: 13
Canonical length: 303 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in positive regulation of fat cell differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q5VYS4|MEDAG
     1  MAGAACEPVA RPSLTSISSG ELRSLWTCDC ELALLPLAQL LRLQPGAFQL SGDQLVVARP
    61  GEPAAARGGF NVFGDGLVRL DGQLYRLSSY IKRYVELTNY CDYKDYRETI LSKPMLFFIN
   121  VQTKKDTSKE RTYAFLVNTR HPKIRRQIEQ GMDMVISSVI GESYRLQFDF QEAVKNFFPP
   181  GNEVVNGENL SFAYEFKADA LFDFFYWFGL SNSVVKVNGK VLNLSSTSPE KKETIKLFLE
   241  KMSEPLIRRS SFSDRKFSVT SRGSIDDVFN CNLSPRSSLT EPLLAELPFP SVLESEETPN
   301  QFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEDAG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 161 nTPM
blood vessel: 139 nTPM
urinary bladder: 62 nTPM
breast: 58 nTPM
heart muscle: 31 nTPM
fallopian tube: 27 nTPM

Single-cell type

decidual stromal cells: 251 nCPM
fibroblasts: 227 nCPM
mesothelial cells: 169 nCPM
fibro-adipogenic progenitors: 85 nCPM
endometrial stromal cells: 75 nCPM
epicardial cells: 57 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 8.5 nTPM
hypothalamus: 3.4 nTPM
cerebral cortex: 2.6 nTPM
basal ganglia: 1.1 nTPM
midbrain: 1.1 nTPM
medulla oblongata: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of fat cell differentiation

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

MEDAG/TEX26

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEDAG as an antibody target. Whether an autoantibody or antibody against MEDAG could matter depends on whether native MEDAG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEDAG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEDAG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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