Seroatlas · Human Serome Atlas

MDS2

Myelodysplastic syndrome 2 translocation-associated protein

Also known as: MDS2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDY4
Gene: MDS2
Canonical length: 140 aa

OverviewNCBI Gene

No narrative summary is available for MDS2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q8NDY4|MDS2
     1  MLQAADFIER TETAGELSRG LIGVLSSQIS WCLLNVNLSK LPTRLQRLSC SVLNSSPAMR
    61  GGARGRPQLT LERPLRPGCR LHSCSEAEKG GFVRRKEIIL FPPCEDPARG WLSANPGREP
   121  SPGICWHLNL GLPSLHNCEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MDS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.38
gnomAD missense Z: 0.95

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

MDS2-like, C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MDS2 as an antibody target. Whether an autoantibody or antibody against MDS2 could matter depends on whether native MDS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MDS2 is annotated as secreted, so native MDS2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MDS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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