MDP1
Magnesium-dependent phosphatase 1
Also known as: FN6Pase, MGC5987, MGDP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86V88
- Gene
- MDP1
- Ensembl
- ENSG00000213920
- Chromosome
- 14
- Canonical length
- 176 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable acid phosphatase activity. Predicted to be involved in chromatin remodeling. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
176 residues, UniProt reviewed canonical sequence.
>Q86V88|MDP1
1 MARLPKLAVF DLDYTLWPFW VDTHVDPPFH KSSDGTVRDR RGQDVRLYPE VPEVLKRLQS
61 LGVPGAAASR TSEIEGANQL LELFDLFRYF VHREIYPGSK ITHFERLQQK TGIPFSQMIF
121 FDDERRNIVD VSKLGVTCIH IQNGMNLQTL SQGLETFAKA QTGPLRSSLE ESPFEALocalizationUniProt · AlphaFold · HPA
Whether an antibody against MDP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 20 nTPM
- pituitary gland: 19 nTPM
- blood vessel: 19 nTPM
- cerebral cortex: 19 nTPM
- kidney: 19 nTPM
- adrenal gland: 18 nTPM
Single-cell type
- renal collecting duct principal cells: 0.5 nCPM
- renal connecting tubule cells: 0.4 nCPM
- podocytes: 0.3 nCPM
- thyrotrophs: 0.3 nCPM
- enteric stem cells: 0.2 nCPM
- epididymal basal cells: 0.2 nCPM
Immune cell
- plasmacytoid DC: 30 nTPM
- eosinophil: 17 nTPM
- T-reg: 16 nTPM
- myeloid DC: 16 nTPM
- intermediate monocyte: 15 nTPM
- classical monocyte: 14 nTPM
Brain region
- white matter: 6.3 nTPM
- spinal cord: 4.9 nTPM
- cerebellum: 4.4 nTPM
- cerebral cortex: 4.4 nTPM
- hypothalamus: 4.2 nTPM
- pons: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.53
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- HAD superfamily
- HAD-like superfamily
- HAD-superfamily phosphatase, subfamily IIIC
- Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type
- Magnesium-dependent phosphatase-1, eukaryotic-type
- Acid Phosphatase
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MDP1 as an antibody target. Whether an autoantibody or antibody against MDP1 could matter depends on whether native MDP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MDP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MDP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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