Seroatlas · Human Serome Atlas

MDM1

Nuclear protein MDM1

Also known as: MDM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC05
Gene: MDM1
Ensembl: ENSG00000111554
Chromosome: 12
Canonical length: 714 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]

Canonical amino-acid sequenceUniProt

714 residues, UniProt reviewed canonical sequence.

>Q8TC05|MDM1
     1  MPVRFKGLSE YQRNFLWKKS YLSESCNSSV GRKYPWAGLR SDQLGITKEP SFISKRRVPY
    61  HDPQISKSLE WNGAISESNV VASPEPEAPE TPKSQEAEQK DVTQERVHSL EASRVPKRTR
   121  SHSADSRAEG ASDVENNEGV TNHTPVNENV ELEHSTKVLS ENVDNGLDRL LRKKAGLTVV
   181  PSYNALRNSE YQRQFVWKTS KETAPAFAAN QVFHNKSQFV PPFKGNSVIH ETEYKRNFKG
   241  LSPVKEPKLR NDLRENRNLE TVSPERKSNK IDDRLKLEAE MELKDLHQPK RKLTPWKHQR
   301  LGKVNSEYRA KFLSPAQYLY KAGAWTHVKG NMPNQVKELR EKAEFYRKRV QGTHFSRDHL
   361  NQILSDSNCC WDVSSTTSSE GTVSSNIRAL DLAGDPTSHK TLQKCPSTEP EEKGNIVEEQ
   421  PQKNTTEKLG VSAPTIPVRR RLAWDTENTS EDVQKQPGEK EEEDDNEEEG DRKTGKQAFM
   481  GEQEKLDVRE KSKADKMKEG SDSSVSSEKG GRLPTPKLRE LGGIQRTHHD LTTPAVGGAV
   541  LVSPSKMKPP APEQRKRMTS QDCLETSKND FTKKESRAVS LLTSPAAGIK TVDPLPLRED
   601  SEDNIHKFAE ATLPVSKIPK YPTNPPGQLP SPPHVPSYWH PSRRIQGSLR DPEFQHNVGK
   661  ARMNNLQLPQ HEAFNDEDED RLSEISARSA ASSLRAFQTL ARAKKRKENF WGKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MDM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

retina: 26 nTPM
testis: 19 nTPM
choroid plexus: 18 nTPM
fallopian tube: 16 nTPM
colon: 15 nTPM
bone marrow: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 119 nCPM
megakaryocytes: 99 nCPM
ependymal cells: 80 nCPM
respiratory ciliated cells: 75 nCPM
pituitary stem cells: 69 nCPM
late primary spermatocytes: 67 nCPM

Immune cell

non-classical monocyte: 18 nTPM
eosinophil: 14 nTPM
intermediate monocyte: 11 nTPM
basophil: 9.7 nTPM
MAIT T-cell: 7.2 nTPM
memory B-cell: 6.8 nTPM

Brain region

choroid plexus: 26 nTPM
spinal cord: 18 nTPM
midbrain: 18 nTPM
medulla oblongata: 17 nTPM
white matter: 15 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear protein MDM1
Nuclear protein MDM1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MDM1 as an antibody target. Whether an autoantibody or antibody against MDM1 could matter depends on whether native MDM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MDM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MDM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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