Seroatlas · Human Serome Atlas

MDFIC2

MyoD family inhibitor domain-containing protein 2

Also known as: MDFI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVS7
Gene
MDFIC2
Ensembl
ENSG00000242120
Chromosome
3
Canonical length
189 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in negative regulation of DNA-templated transcription; regulation of JNK cascade; and regulation of Wnt signaling pathway. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>A0A1B0GVS7|MDFIC2
     1  MSETELEKIK VRTAEHLEND KNNISWLKED TQLTNAKHAD EKPINAIVIN SVSDFNITDG
    61  PAKENPNEKK LSESSTSLSS LEECQTTFSY LQTDTSVHHR DTDEECASLI LACLFCQFWD
   121  CLLMLPGTCE TVCTKMCCPS RRYHHTSDEN HSRNDCSCNC DMDCSLFESC HETSECLELA
   181  MEISEICYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MDFIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 0.7 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • endometrial glandular cells: 10 nCPM
  • oligodendrocytes: 5.4 nCPM
  • oocytes: 4.6 nCPM
  • epicardial cells: 4.5 nCPM
  • mesothelial cells: 3.9 nCPM
  • endometrial luminal cells: 3.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.7 nTPM
  • medulla oblongata: 0.3 nTPM
  • pons: 0.3 nTPM
  • white matter: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • hypothalamus: 0.2 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MDFIC2 as an antibody target. Whether an autoantibody or antibody against MDFIC2 could matter depends on whether native MDFIC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MDFIC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MDFIC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MDFIC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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