Seroatlas · Human Serome Atlas

MCIDAS

Multicilin

Also known as: IDAS, MCI, MCIN, MCIN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
D6RGH6
Gene
MCIDAS
Ensembl
ENSG00000234602
Chromosome
5
Canonical length
385 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>D6RGH6|MCIDAS
     1  MQACGGGAAG RRAFDSICPN RMLALPGRAL LCKPGKPERK FAPPRKFFPG CTGGSPVSVY
    61  EDPPDAEPTA LPALTTIDLQ DLADCSSLLG SDAPPGGDLA ASQNHSHQTE ADFNLQDFRD
   121  TVDDLISDSS SMMSPTLASG DFPFSPCDIS PFGPCLSPPL DPRALQSPPL RPPDVPPPEQ
   181  YWKEVADQNQ RALGDALVEN NQLHVTLTQK QEEIASLKER NVQLKELASR TRHLASVLDK
   241  LMITQSRDCG AAAEPFLLKA KAKRSLEELV SAAGQDCAEV DAILREISER CDEALQSRDP
   301  KRPRLLPEPA NTDTRPGNLH GAFRGLRTDC SRSALNLSHS ELEEGGSFST RIRSHSTIRT
   361  LAFPQGNAFT IRTANGGYKF RWVPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCIDAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
2.6 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 2.6 nTPM
  • stomach: 1.1 nTPM
  • thyroid gland: 0.8 nTPM
  • pancreas: 0.5 nTPM
  • epididymis: 0.2 nTPM
  • fallopian tube: 0.2 nTPM

Single-cell type

  • respiratory deuterosomal cells: 57 nCPM
  • respiratory secretory cells: 7.3 nCPM
  • gastric chief cells: 2.2 nCPM
  • foveolar cells: 1.9 nCPM
  • respiratory basal cells: 1.4 nCPM
  • gastric progenitor cells: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.3 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCIDAS.

Disease | AllUniProt

Conditions MCIDAS is implicated in, by any mechanism.

  • Ciliary dyskinesia, primary, 42 (CILD42) MIM:618695

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 239 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0.01
gnomAD missense Z
1.88
DepMap mean gene effect
-0.21
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCIDAS as an antibody target. Whether an autoantibody or antibody against MCIDAS could matter depends on whether native MCIDAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCIDAS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCIDAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCIDAS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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