Seroatlas · Human Serome Atlas

MCHR2

Melanin-concentrating hormone receptor 2

Also known as: GPR145, MCH2, MCH2R, MCHR2_HUMAN, SLT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969V1
Gene: MCHR2
Ensembl: ENSG00000152034
Chromosome: 6
Canonical length: 340 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q969V1|MCHR2
     1  MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV GNILIVFTII
    61  RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC
   121  SAIMTVMSVD RYFALVQPFR LTRWRTRYKT IRINLGLWAA SFILALPVWV YSKVIKFKDG
   181  VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS
   241  VPKQRVMKLT KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
   301  INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCHR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 5.1 nTPM
testis: 1.4 nTPM
amygdala: 1.1 nTPM
basal ganglia: 0.5 nTPM
hippocampal formation: 0.2 nTPM
bone marrow: 0.1 nTPM

Single-cell type

brain excitatory neurons: 20 nCPM
brain inhibitory neurons: 7.9 nCPM
retinal amacrine cells: 6.2 nCPM
late spermatids: 4.4 nCPM
retinal pigment epithelial cells: 4.3 nCPM
late primary spermatocytes: 3.4 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 11 nTPM
basal ganglia: 6.2 nTPM
white matter: 4.4 nTPM
amygdala: 4 nTPM
hippocampal formation: 2.6 nTPM
hypothalamus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Melanin-concentrating hormone receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Melanin-concentrating hormone receptor 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCHR2 as an antibody target. Whether an autoantibody or antibody against MCHR2 could matter depends on whether native MCHR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCHR2 is annotated at the cell surface, where native MCHR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MCHR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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