MCHR1

Protein identityUniProt · HPA

UniProt accession

Q99705

Gene

MCHR1

Ensembl

ENSG00000128285

Chromosome

22

Canonical length

353 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q99705|MCHR1
     1  MDLEASLLPT GPNASNTSDG PDNLTSAGSP PRTGSISYIN IIMPSVFGTI CLLGIIGNST
    61  VIFAVVKKSK LHWCNNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT
   121  AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSVA TLVICLLWAL SFISITPVWL
   181  YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVR ILQRMTSSVA
   241  PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG
   301  YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRAVSNA QTADEERTES KGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCHR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

9.9 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for MCHR1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

-0.75

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• feeding behavior
• G protein-coupled receptor signaling pathway
• generation of precursor metabolites and energy
• neuropeptide signaling pathway
• positive regulation of calcium ion transport
• positive regulation of cytosolic calcium ion concentration

Molecular functions

• G protein-coupled receptor activity
• hormone binding
• neuropeptide binding
• neuropeptide receptor activity
• signaling receptor binding
• melanin-concentrating hormone receptor activity

Cellular components

• ciliary membrane
• cilium
• neuron projection
• non-motile cilium
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Melanin-concentrating hormone receptor
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Melanin-concentrating hormone receptor 1

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MCHR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NCDN