Seroatlas · Human Serome Atlas

MCEMP1

Mast cell-expressed membrane protein 1

Also known as: C19orf59, MCEM1_HUMAN, MGC132456

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IX19
Gene
MCEMP1
Ensembl
ENSG00000183019
Chromosome
19
Canonical length
187 aa
Protein class
Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q8IX19|MCEMP1
     1  MEVEEIYKHQ EVKMQAPAFR DKKQGVSAKN QGAHDPDYEN ITLAFKNQDH AKGGHSRPTS
    61  QVPAQCRPPS DSTQVPCWLY RAILSLYILL ALAFVLCIIL SAFIMVKNAE MSKELLGFKR
   121  ELWNVSNSVQ ACEERQKRGW DSVQQSITMV RSKIDRLETT LAGIKNIDTK VQKILEVLQK
   181  MPQSSPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCEMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • lung: 83 nTPM
  • bone marrow: 77 nTPM
  • spleen: 50 nTPM
  • appendix: 24 nTPM
  • smooth muscle: 6.3 nTPM
  • urinary bladder: 5.7 nTPM

Single-cell type

  • neutrophils: 83 nCPM
  • neutrophil progenitors: 18 nCPM
  • monocytes: 11 nCPM
  • monocyte progenitors: 9.8 nCPM
  • platelets: 8.5 nCPM
  • macrophages: 2.3 nCPM

Immune cell

  • classical monocyte: 124 nTPM
  • neutrophil: 58 nTPM
  • total PBMC: 47 nTPM
  • myeloid DC: 18 nTPM
  • intermediate monocyte: 7.4 nTPM
  • eosinophil: 3.4 nTPM

Brain region

  • cerebral cortex: 6.2 nTPM
  • thalamus: 2.9 nTPM
  • pons: 2.8 nTPM
  • basal ganglia: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • cerebellum: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mast cell-expressed membrane protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCEMP1 as an antibody target. Whether an autoantibody or antibody against MCEMP1 could matter depends on whether native MCEMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCEMP1 is annotated at the cell surface, where native MCEMP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MCEMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCEMP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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