Seroatlas · Human Serome Atlas

MCCD1

Mitochondrial coiled-coil domain protein 1

Also known as: MCCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P59942
Gene
MCCD1
Ensembl
ENSG00000204511
Chromosome
6
Canonical length
119 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>P59942|MCCD1
     1  MVLPLPWLSR YHFLRLLLPS WSLAPQGSHG CCSQNPKASM EEQTSSRGNG KMTSPPRGPG
    61  THRTAELARA EELLEQQLEL YQALLEGQEG AWEAQALVLK IQKLKEQMRR HQESLGGGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 120 nTPM
  • breast: 1.2 nTPM
  • skeletal muscle: 0.4 nTPM
  • bone marrow: 0.1 nTPM
  • heart muscle: 0.1 nTPM
  • pancreas: 0.1 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 1.4 nCPM
  • distal convoluted tubule cells: 1 nCPM
  • proximal tubule cells: 1 nCPM
  • loop of henle epithelial cells: 0.8 nCPM
  • renal connecting tubule cells: 0.7 nCPM
  • podocytes: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • medulla oblongata: 1.4 nTPM
  • pons: 1.2 nTPM
  • hypothalamus: 1 nTPM
  • thalamus: 1 nTPM
  • white matter: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
gnomAD missense Z
-0.39
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mitochondrial coiled-coil domain protein 1
  • Mitochondrial coiled-coil domain protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCCD1 as an antibody target. Whether an autoantibody or antibody against MCCD1 could matter depends on whether native MCCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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