MBLAC2
Acyl-coenzyme A thioesterase MBLAC2
Also known as: DKFZp686P15118, MBLC2_HUMAN, MGC46734
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q68D91
- Gene
- MBLAC2
- Ensembl
- ENSG00000176055
- Chromosome
- 5
- Canonical length
- 279 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
Enables beta-lactamase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
279 residues, UniProt reviewed canonical sequence.
>Q68D91|MBLAC2
1 MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL RSLPEYLYSS
61 GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV HHAEAEALAR GDNFETVTWL
121 SDSEVVRTPS PGWRARQFRV QAVQPTLILQ DGDVINLGDR QLTVMHMPGH SRGSICLHDK
181 DRKILFSGDV VYDGSLIDWL PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL
241 FRLASNYISK AGICHKVSTF AMRSLASLAL RVTNSRTSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MBLAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 7.6 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 7.6 nTPM
- ovary: 7 nTPM
- cerebral cortex: 6.5 nTPM
- cerebellum: 6.1 nTPM
- liver: 5.9 nTPM
- hypothalamus: 5.2 nTPM
Single-cell type
- cone photoreceptor cells: 39 nCPM
- corticotrophs: 29 nCPM
- other brain neurons: 22 nCPM
- brain inhibitory neurons: 22 nCPM
- adrenal medulla cells: 21 nCPM
- brain excitatory neurons: 20 nCPM
Immune cell
- naive B-cell: 2.4 nTPM
- naive CD4 T-cell: 2 nTPM
- intermediate monocyte: 1.8 nTPM
- MAIT T-cell: 1.6 nTPM
- naive CD8 T-cell: 1.6 nTPM
- NK-cell: 1.6 nTPM
Brain region
- hypothalamus: 16 nTPM
- midbrain: 14 nTPM
- cerebral cortex: 13 nTPM
- cerebellum: 13 nTPM
- hippocampal formation: 13 nTPM
- white matter: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.59
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Metallo-beta-lactamase
- Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
- Metallo-beta-lactamase superfamily
- Metallo-beta-lactamase type 2-like
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MBLAC2 as an antibody target. Whether an autoantibody or antibody against MBLAC2 could matter depends on whether native MBLAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MBLAC2 is annotated at the cell surface, where native MBLAC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MBLAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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