Seroatlas · Human Serome Atlas

MBLAC1

Metallo-beta-lactamase domain-containing protein 1

Also known as: MBLC1_HUMAN, MGC49416

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A4D2B0
Gene
MBLAC1
Ensembl
ENSG00000214309
Chromosome
7
Canonical length
266 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables RNA endonuclease activity and metal ion binding activity. Involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>A4D2B0|MBLAC1
     1  MRTEPLCGAS PLLVPGDPYS VVVLLQGYAE PEGVGDAVRA DGSVTLVLPQ TRGPASSHRE
    61  SPRGSGGAEA ALEEAARGPI LVDTGGPWAR EALLGALAGQ GVAPGDVTLV VGTHGHSDHI
   121  GNLGLFPGAA LLVSHDFCLP GGRYLPHGLG EGQPLRLGPG LEVWATPGHG GQRDVSVVVA
   181  GTALGTVVVA GDVFERDGDE DSWQALSEDP AAQERSRKRV LVVADVVVPG HGPPFRVLRE
   241  ASQPETEGGG NSQQEPVVGD EEPALH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBLAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
8.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 8.6 nTPM
  • cerebral cortex: 8 nTPM
  • basal ganglia: 5.5 nTPM
  • amygdala: 5.4 nTPM
  • hippocampal formation: 5.3 nTPM
  • prostate: 4.7 nTPM

Single-cell type

  • esophageal apical cells: 32 nCPM
  • cardiomyocytes: 24 nCPM
  • epididymal efferent duct absorptive cells: 13 nCPM
  • gastric chief cells: 7.6 nCPM
  • myosatellite cells: 7.2 nCPM
  • breast lactating cells: 7.1 nCPM

Immune cell

  • naive B-cell: 0.9 nTPM
  • neutrophil: 0.9 nTPM
  • eosinophil: 0.7 nTPM
  • naive CD4 T-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 17 nTPM
  • cerebellum: 17 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 12 nTPM
  • hippocampal formation: 10 nTPM
  • pons: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MBLAC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0.21
gnomAD missense Z
1.2
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBLAC1 as an antibody target. Whether an autoantibody or antibody against MBLAC1 could matter depends on whether native MBLAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBLAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBLAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MBLAC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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