Seroatlas · Human Serome Atlas

MATCAP2

Putative tyrosine carboxypeptidase MATCAP2

Also known as: KIAA0895, MACA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCT3
Gene: MATCAP2
Ensembl: ENSG00000164542
Chromosome: 7
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable carboxypeptidase activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8NCT3|MATCAP2
     1  MAGCTRKLTH LRKRIHRPRR RTTRRWKRWF KFRKRKGEKR PRPNHKAVAR RAKLKFSTSE
    61  KLHWPEQELA KKSILNAEDS LIIDNKRSIS HLSSGVLKDI FTTGTSSYNV LLQSKEEKKY
   121  HSQKQSSSTY SKRCRKPSKS PNTSRSKDPR RMKALVPVTS SGTWYCLERR PAVFVTSSVS
   181  SPVKFTHDIS VTGNGIVLPP KPKSKVKWCH FSTLPKPKPQ LSRSFEKGDD FSGKKFCILT
   241  AIKPTNLEKE KLRFFKSDYT YNPQFEYANP ALPSVLAKHS HASDRFLKQI VVHLTEDLLS
   301  RASMTVVNGC PTLTINVSTA REHWLEGMLR HEIGTHYFRG INNLQQPWNS WTGRKKHELK
   361  PNNPTEEGLA SIHSVLFRKD PFLWRAALLY YTVYQASQMS FCELFKDIGR FVKDPNTRWD
   421  YCVRAKRGWT DTSQPGCFSK DQVYLDGILQ ILRYRDTIDF HLLTALGKVS YEDVDRLKGL
   481  AVTENMRVPH FLQDHGRYME HLEKIMEVNE LTDRELKDLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MATCAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
cerebellum: 15 nTPM
retina: 14 nTPM
parathyroid gland: 11 nTPM
stomach: 11 nTPM
pancreas: 8.6 nTPM

Single-cell type

early spermatids: 122 nCPM
late spermatids: 108 nCPM
endometrial ciliated cells: 107 nCPM
gastric chief cells: 105 nCPM
cone photoreceptor cells: 101 nCPM
parietal cells: 101 nCPM

Immune cell

T-reg: 0.2 nTPM
basophil: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebellum: 34 nTPM
choroid plexus: 27 nTPM
hypothalamus: 23 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 16 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MATCAP2 as an antibody target. Whether an autoantibody or antibody against MATCAP2 could matter depends on whether native MATCAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MATCAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MATCAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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